A new α-Pyrone from the gorgonian-derived fungus Penicillium chrysogenum
Objective To study the secondary metabolites from the gorgonian-derived fungus Penicillium chrysogenum(TA 10-16)and their biological activities.Methods The structure of the compounds were identified by comprehensive spectroscopic data,including 1D/2D NMR,HRESIMS and ECD.Results Seven polyketide compounds were isolated from a marine fungus Penicillium sp.,including a new α-Pyrone(1)and six known compounds(2-7),which were pyrenocine E(2),zanthopyranone(3),emodin 8-O-methylether(4),questinol(5),(2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol(6),and 4-hydroxybenzaldehyde(7).Compounds 1 and 6 showed moderate antifungal activity against Candida albicans with the same MIC values of 12.5 μmol/L,while compound 7 showed weak activity against C.albicans with the MIC value of 25.0 μmol/L.Conclusion The structure of compound 1 was elucidated by comprehensive spectroscopic data including 1D/2D NMR,HRESIMS and ECD.At the same time,compounds 1 and 6 had potential antifungal activity through activity test.
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