柳珊瑚来源真菌 Penicillium chrysoygenum中的1个新的α吡喃酮发现
A new α-Pyrone from the gorgonian-derived fungus Penicillium chrysogenum
薛莹 1周月 2张雅慧 2杨毅 3王长云2
作者信息
- 1. 中国海洋大学海洋药物教育部重点实验室,医药学院,山东青岛 266003;青岛海洋科学与技术国家实验室海洋药物与生物制品功能实验室,山东青岛 266237;山西高等创新研究院,山西太原 030032
- 2. 中国海洋大学海洋药物教育部重点实验室,医药学院,山东青岛 266003;青岛海洋科学与技术国家实验室海洋药物与生物制品功能实验室,山东青岛 266237
- 3. 太原理工大学光电工程学院,山西太原 030024
- 折叠
摘要
目的 柳珊瑚来源真菌Penicillium chrysogenum(TA10-16)次级代谢产物及其生物活性研究.方法 通过广泛的波谱数据,包括1D/2D NMR,HRESIMS和ECD谱从而确定化合物的结构.结果 共分离获得7个聚酮化合物,包括1个新的α-Pyrone(1)和6个已知化合物(2～7),分别是pyrenocine E(2)、zanthopyra-none(3)、emodin 8-O-methylether(4)、questinol(5)、(2S,3SS)-1-(4-hydroxyphenyl)butane-2,3-diol(6)和4-hydroxybenzaldehyde(7).化合物1和6对白色念珠菌表现出中等的抗真菌活性,最低抑菌浓度(MIC)为12.5 μmol/L,而化合物7对白色念珠菌的MIC则为25.0 μmol/L.结论 化合物1的结构通过1D/2D NMR、HRESIMS和ECD等综合光谱数据进行了鉴定.同时,通过活性测试,化合物1和6具有潜在的抗真菌活性.
Abstract
Objective To study the secondary metabolites from the gorgonian-derived fungus Penicillium chrysogenum(TA 10-16)and their biological activities.Methods The structure of the compounds were identified by comprehensive spectroscopic data,including 1D/2D NMR,HRESIMS and ECD.Results Seven polyketide compounds were isolated from a marine fungus Penicillium sp.,including a new α-Pyrone(1)and six known compounds(2-7),which were pyrenocine E(2),zanthopyranone(3),emodin 8-O-methylether(4),questinol(5),(2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol(6),and 4-hydroxybenzaldehyde(7).Compounds 1 and 6 showed moderate antifungal activity against Candida albicans with the same MIC values of 12.5 μmol/L,while compound 7 showed weak activity against C.albicans with the MIC value of 25.0 μmol/L.Conclusion The structure of compound 1 was elucidated by comprehensive spectroscopic data including 1D/2D NMR,HRESIMS and ECD.At the same time,compounds 1 and 6 had potential antifungal activity through activity test.
关键词
柳珊瑚来源/Penicillium/chrysogenum/聚酮/ECD/抗真菌活性Key words
gorgonian-derived fungus/Penicillium chrysogenum/polyketide/ECD/antifungal activity引用本文复制引用
基金项目
山东省自然科学基金(ZR2019ZD18)
出版年
2024
NETL
NSTL
万方数据