A new antitumor thiodiketopiperazine from the marine-derived fungus Aspergillus sp.HH-3
Objective To study the cytotoxic secondary metabolites of the marine-derived fungus Aspergillus sp.HH-3.Methods The crude metabolite was purified by silica gel and sephadex LH-20 chromatography.The structures of the compounds were elucidated by MS and NMR analysis.The cytotoxities of the compounds against three tumor cells(A549,HepG2,HeLa)were evaluated using CCK-8 method.Results Six compounds were isolated from the marine-derived fungus Aspergillus sp.HH-3 including one new compound aspersin(1),and five known ones dehydroxymethylbis(dethio)bis(methylthio)gliotoxin(2),trypacidin(3),monomethylsubchrin(4),verruculogen(5)and chaetominine(6).Compounds 1,2,and 6 showed moderate cytotoxic activities against tumour cells of A549,HepG2 and HeLa.Conclusion Compound 1 is a new thiodiketopiperazine.Compounds 1,2,and 6 exhibit moderate antitumor activity.
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