Preparation and anti-tumor activity of chitosan composite hydrogel
Objective To prepare chitosan composite hydrogel with photothermal properties and loaded with antitumor drugs,and to study its antitumor activity.Methods Chitosan was used as a material for the green preparation of gold nanoparticles(GNPs),and olaparib-loaded liposomes(OLP)were prepared by the film dispersion method.The composite hydrogel co-loaded GNPs and OLP.Based on the characterization of its morphology and rheology,the antitumor activity of the composite hydrogel was evaluated.Results The prepared gold nanoparticles were uniformly dispersed with a particle size of(61.97±1.77)nm.The drug loading and encapsulation efficiency of olaparib-loaded liposomes were(9.97±0.59)％and(55.34±1.22)％,respectively.The chitosan composite hydrogel had good injectability and biocompatibility,and showed good photothermal conversion ability.Cytotoxicity experiments showed that the chitosan composite hydrogel exhibited stronger 4T1 cell inhibition ability than olaparib hydrogel under 808 nm light.Conclusion The chitosan composite hydrogel combined the hydrophobic drug olaparib with hydrophilic GNPs,showing good anti-tumor application prospects by combining photothermal therapy and chemotherapy.
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