Synthesis of tetrahydropyrrole skeleton of dragocin family marine natural products
Objective The synthetic study on dragocin family marine natural products was conducted.The construction of core tetrahydropyrrole skeleton was accomplished.Methods The target compound was synthesized from dioxanone and aminoacetaldehyde derivatives through organocatalytic aldol,tandem hydrogenation/reductive amination,migration,oxidation,and Grignard reaction.Results The synthesis of core tetrahydropyrrole skeleton in dragocin family marine natural products was completed in 6 steps with 22％yield,providing a foundation for total synthesis of natural products.
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