Research progress of personalized treatment for cancer patients with chemotherapy drugs using genomics and quantitative pharmacology
Cancer is a major disease that threatens public health and seriously endangers human life and health security.It is one of the leading causes of death worldwide.Currently,the use of chemotherapy drugs is preferred for advanced cancer patients who have lost the opportunity for surgical cure.However,the treatment effects and adverse effects pose significant challenges to the treatment,severely impacting the quality of life for patients.Therefore,personalized treatment with chemotherapy drugs is important for improving treatment effectiveness and reducing side effects.Personalized treatments based on genomics and quantitative pharmacology have begun to break the boundaries of traditional medicine and have become an important direction in precision medicine research.This article reviews the research progress in genomics and quantitative pharmacology related to four common chemotherapy drugs:oxaliplatin,marine drug irinotecan,and capecitabine,as well as paclitaxel.
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