摘要
目的 观察甲巯咪唑联合硒酵母片治疗甲状腺功能亢进症的临床疗效和安全性.方法 选择甲状腺功能亢进症患者130例,采用随机数字表法分为甲巯咪唑联合硒酵母片治疗组(ATD+Se组)65例和甲巯咪唑治疗组(ATD组)65例,观察两组治疗前后甲状腺功能指标、甲状腺抗体指标以及不良反应发生情况.结果 ATD+Se组治疗后血清游离三碘甲状腺原氨酸(FT3)为(3.32±0.53)pg/mL、血清游离四碘甲状腺原氨酸(FT4)为(1.02±0.17)ng/dL、促甲状腺激素(TSH)为(2.72±0.32)mIU/L,ATD组治疗后FT3为(4.82±0.75)pg/mL、FT4为(2.41±0.32)ng/dL、TSH为(2.72±0.32)mIU/L,两组分别与治疗前相比,ATD+Se组变化幅度优于ATD组,差异均有统计学意义(t=4.591、3.814、3.567,均P<0.05);ATD+Se组治疗后抗甲状腺过氧化酶抗体(TPOAb)为(120.3±23.1)IU/mL、抗甲状腺球蛋白抗体(TGAb)为(123.3±26.5)IU/mL、促甲状腺受体抗体(TRAb)为(1.72±0.89)IU/mL,ATD组治疗后TPOAb为(132.8±21.1)IU/mL、TGAb为(134.8±21.3)IU/mL、TRAb为(3.68±1.06)IU/mL,两组分别与治疗前相比,ATD+Se组上述指标变化幅度更大,差异均有统计学意义(t=4.291、3.514、3.767,均P<0.05);ATD+Se组治疗总有效率(90.77％)优于ATD组(76.92％),差异有统计学意义(χ2=13.147,P<0.05);ATD+Se组不良反应发生率(12.31％)低于ATD组(27.69％),差异有统计学意义(χ2=18.685,P<0.05).结论 甲巯咪唑联合硒酵母片治疗甲状腺功能亢进症,是一种安全有效的治疗方法.
Abstract
Objective To assess the efficacy and safety of methimazole combined with selenium therapy in the treatment of hyperthyroidism .Methods 130 cases with hyperthyroidism were selected , and according to the digital table they were randomly divided into methimazole plus selenium treatment group ( ATD +Se group ) and methimazole treatment group(ATD group),65 cases in each group.The patients were followed up for 3 months.The thyroid function index and thyroid antibody index were observed before and after treatment .The adverse reactions were observed,too.Results After treatment,the serum levels of FT3,FT4,TSH in the ATD +Se group were (3.32 ± 0.53)pg/mL,(1.02 ±0.17)ng/dL,(2.72 ±0.32)mIU/L,respectively,which in the ATD group were (4.82 ± 0.75)pg/mL,(2.41 ±0.32)ng/dL,(2.72 ±0.32)mIU/L,respectively.The change ranges of the ATD +Se group were better than those of the ATD group ,the differences were statistically significant (t=4.591,3.814,3.567,all P<0.05).The TPOAb,TGAb,TRAb in the ATD+Se group were (120.3 ±23.1) IU/mL,(123.3 ±26.5) IU/mL, (1.72 ±0.89)IU/mL,respectively,which in the ATD group were (132.8 ±21.1)IU/mL,(134.8 ±21.3)IU/mL, (3.68 ±1.06)IU/mL,respectively.The changes of the ATD+Se group were more significant than those of the ATD group,the differences were statistically significant (t=4.291,3.514,3.767,all P<0.05 ).The total effective rate of the ATD+Se group was higher than that of the ATD group (90.77％vs.76.92％χ2 =13.147,P<0.05 ).The incidence rate of adverse reactions in the ATD +Se group was lower than that in the ATD group (12.31％vs.27.69％χ2 =18.685,P<0.05 ).Conclusion The results suggest that methimazole combined with selenium treatment is effective and safe for hyperthyroidism .
基金项目
广东省江门市科技计划项目(江科 2015 81号-5)
NETL
NSTL
维普
万方数据