左乙拉西坦治疗儿童及青少年癫痫临床分析
Clinical analysis of levetiracetam in the treatment of children and adolescents with epilepsy
吴名展 1陈伊洁 2郭晓成 1何素丽 3马兰香4
作者信息
- 1. 广东省,汕头潮南民生医院神经内科 515144
- 2. 广东省,汕头市潮阳区人民医院儿科 515100
- 3. 广东省,汕头潮南民生医院儿科 515144
- 4. 广东省,汕头潮南民生医院脑电图室 515144
- 折叠
摘要
目的 探讨以及比较左乙拉西坦片及丙戊酸钠缓释片对儿童及青少年癫痫患者的临床疗效.方法 选择2017年4月至2018年4月汕头潮南民生医院收治的儿童及青少年癫痫患者80例,按抽签分组方式分为两组,每组40例.观察组采用左乙拉西坦片治疗,对照组采用丙戊酸钠缓释片治疗.比较两组患者治疗前后脑电图改善情况、治疗总有效率与不良反应发生率.结果 观察组治疗6个月后脑电图改善率为41.17％,而对照组为45.71％,两组差异无统计学意义(x2=0.508,P＞0.05);观察组治疗9个月脑电图改善率为70.58％,对照组为74.28％,两组差异无统计学意义(x2=0.225,P＞0.05).观察组治疗总有效率(92.50％)与对照组治疗总有效率(95.00％)相比,差异无统计学意义(x2=0.354,P＞0.05);观察组总不良反应发生率为22.50％,明显低于对照组的45.00％,差异有统计学意义(x2=6.864,P＜0.05).结论 丙戊酸钠缓释片和左乙拉西坦片治疗儿童及青少年癫痫均具有较高的有效性和安全性,但左乙拉西坦不良反应更少,值得在临床单药治疗儿童及青少年癫痫方面进行推广.
Abstract
Objective To explore and compare the clinical efficacy of levetiracetam tablets and compound sodium valproate sustained release tablets in the treatment of children and adolescents with epilepsy.Methods From April 2017 to April 2018,80 children and adolescents with epilepsy treated in Chaonan Minsheng Hospital of Shantou were selected as study objects,and they were randomly divided into two groups by drawing lots,with 40 cases in each group.The observation group was given levetiracetam tablets,and the control group was treated with valproate.The improvement of EEG after therapy,the total effective rate,and the incidence of adverse reactions were observed and evaluated.Results The EEG improvement rates after treatment for 6 months in the observation group and control group were 41.17％,45.71％,respectively,the difference was not statistically significant(x2 =0.508,P ＞0.05).The EEG improvement rates after treatment for 9 months in the observation group and control group were 70.58％,74.28％,respectively,the difference was not statistically significant (x2 =0.225,P ＞ 0.05).The total effective rate in the observation group was 92.50％,which was 95.00％ in the control group,the difference was not statistically significant between the two groups (x2 =0.354,P ＞ 0.05).However,the incidence rate of adverse reactions of the observation group(22.50％) was significantly lower than that of the control group(45.00％)(x2 =6.864,P ＜ 0.05).Conclusion Both levetiracetam tablets and compound sodium valproate sustained release tablets have appreciable efficacy and safety in the treatment of epilepsy in children and adolescents,but levetiracetam therapy has less adverse reactions,which deserves further promotion in monotherapy of epilepsy in children and adolescents.
关键词
癫痫/脑电描记术/治疗结果/药物副反应报告系统/丙戊酸钠/左乙拉西坦/儿童/青少年Key words
Epilepsy/Electroencephalography/Treatment outcome/Adverse drug reaction reporting systems/Sodium valproate/Levetiracetam/Child/Adolescent引用本文复制引用
基金项目
广东省汕头市重点科技项目(汕府科[2017]119号)
出版年
2019
NETL
NSTL
维普
万方数据