Objective To investigate the clinical characteristics and drug resistance of Klebsiella pneumoniae infections at different systems,providing laboratory reference for the rational use of antibiotics in clinical practice.Methods The clinical characteristics and drug resistance of patients with Klebsiella pneumoniae infections in respiratory,urinary,hematologic,and other systems who received treatment in Wuzhou Red Cross Hospital from January 2015 to December 2021 were analyzed.Results From 2015 to 2021,there were.3 496 cases of Klebsiella pneumoniae infections in the hospital,among which the respiratory system was most affected with 2 250 strains(64.34％).The sex ratio of patients with Klebsiella pneumoniae infections at different systems was statistically significant(x2=266.77,P＜0.001).The respiratory system and hematological system were more commonly infected by Klebsiella pneumoniae in men,while the urinary system was more commonly infected in women.The sex ratio of patients with Klebsiella pneumoniae infections at other systems were similar.The age distribution of patients with Klebsiella pneumoniae infections at different systems was significantly different(x2=176.54,P＜0.001).Klebsiella pneumoniae infections of the respiratory,urinary,and hematological systems were the most common in people aged＞60-80 years,while Klebsiella pneumoniae infections in other systems were mainly found in people aged＞18-60 years.There were significant differences in the distribution of departments among different Klebsiella pneumoniae infection systems(x2=1 415.30,P＜0.001).The ICU had the highest incidence of Klebsiella pneumoniae infections in the respiratory system,while the department of internal medicine had the highest incidence of Klebsiella pneumoniae infections in the urinary and hematological systems,and the department of surgery had the highest incidence of Klebsiella pneumoniae infections in other parts of the body.The resistance rate of Klebsiella pneumoniae to common antibiotics for the hematologic system was lower than that of the other three infection systems.For infections in the respiratory system,urinary system,and other body parts,the resistance rates of Klebsiella pneumoniae to amikacin,meropenem,imipenem,and piperacillin/tazobactam were all below 10％,while the resistance rate to tobramycin was below 20％,and the resistance rate to cephalosporins was around 30％.Conclusion The proportion of Klebsiella pneumoniae infections in different body parts varies by gender,age,and department.For Klebsiella pneumoniae infections in the hematological system,the resistance rate to commonly used antibiotics is lower than that for infections in the other three systems.In contrast,Klebsiella pneumoniae infections in the respiratory system,urinary system,and other systems have a particularly high resistance rate to third-and fourth-generation cephalosporins but are still sensitive to piperacillin/tazobactam and carbapenem antibiotics.
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