Objective To explore the effects of amlodipine combined with different doses of atorvastatin and simvastatin on hypertension complicated by atherosclerosis.Methods A retrospective analysis was conducted on the clinical data of 100 patients with hypertension complicated by atherosclerosis who were diagnosed and treated at Jinan 2nd People's Hospital from August 2019 to August 2020.These patients were divided into control group(n=32,amlodipine combined with simvastatin),study group 1(n=34,amlodipine combined with 10 mg/day atorvastatin),and study group 2(n=34,amlodipine combined with 20 mg/day atorvastatin)according to different treatment schemes.All three groups were treated for 6 months.The clinical efficacy,blood lipid level,blood pressure,oxidative stress level,carotid intima-media thickness and plaque area were compared among the three groups.Results The overall response rates of the control group,study group 1,and study group 2 were 71.88％(23/32),82.35％(28/34),and 91.18％(31/34),respectively.The difference in overall response rate among the three groups was statistically significant(x2=4.16,P＜0.05).After treatment,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,24-hour dynamic blood pressure,diurnal blood pressure,nighttime blood pressure,malondialdehyde,superoxide dismutase,glutathione peroxidase,carotid intima-media thickness and plaque area were statistically different among the three groups(F=-19.54,-76.61,11.15,-56.83,-147.35,-23.10,-11.47,-11.65,-128.36,-15.60,-24.52,25.61,118.99,-59.23,-81.64,all P＜0.05).The incidence rates of adverse reactions in the control group,study group 1,and study group 2 were 12.50％(4/32),8.82％(3/34),and 11.76％(4/34),respectively.There was no statistically significant difference among the three groups(x2=0.25,P=0.611).Conclusion Amlodipine combined with atorvastatin is more effective in the treatment of hypertension complicated by atherosclerosis than the amlodipine combined with simvastatin.High-dose atorvastatin is more effective in reducing lipid,controlling blood pressure,improving the level of oxidative stress and clinical symptoms compared with low-dose atorvastatin.
NETL
NSTL
万方数据
维普
