Correlation between serum Nesfatin-1,N-terminal pro-brain natriuretic peptide,and cystatin C levels and myocardial enzymes and cardiac function in patients with ST-elevation myocardial infarction
Objective To correlate serum Nesfatin-1,N-terminal pro-brain natriuretic peptide(NT-proBNP),and cystatin C(CysC)levels with myocardial enzymes and cardiac function in patients with acute ST-elevation myocardial infarction(STEMI).Methods This is a case-control study.A total of 100 patients with acute STEMI who received treatment at Lishui People's Hospital from January 2020 to December 2022 were included in the STEMI group.An additional 80 healthy controls who concurrently received physical examinations in the same hospital were included in the control group.Serum levels of Nesfatin-1,NT-proBNP,CysC,creatine kinase-MB(CK-MB),and cardiac troponin Ⅰ(cTnⅠ)levels were determined in each group.Left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVDD),and left ventricular end-systolic diameter(LVDS)were measured using color Doppler ultrasound.Correlation analysis was performed.Results Serum Nesfatin-1 level in the STEMI group was(89.96±15.25)ng/L,which was significantly lower than(226.36±37.47)ng/L in the control group(t=33.15,P＜0.05).Serum levels of NT-proBNP and CysC in the STEMI group were(1 325.12±378.48)ng/L and(1.37±0.24)mg/L,which were significantly higher than(78.95±13.42)ng/L and(0.79±0.16)mg/L in the control group(t=-29.42,-18.56,both P＜0.05).Serum CK-MB and cTnⅠ levels in the STEMI group were(46.51±12.14)U/L and(1.13±0.25)U/L,respectively,which were significantly higher than(12.23± 4.01)U/L and(0.09±0.02)U/L in the control group(t=-24.06,-37.09,both P＜0.05).The LVEF in the STEMI group was(37.84±5.45)％,which was significantly lower than(72.41±4.26)％in the control group(t=46.49,P＜0.05).The LVDD and LVDS in the STEMI group were(40.92±5.25)mm and(58.98±6.25)mm,which were significantly higher than(19.86±3.36)mm and(34.21±4.38)mm in the control group(t=-31.13,-30.03,bothP＜0.05).Serum Nesfatin-1 level was positively correlated with LVEF(r=0.572),but it was negatively correlated with serum CK-MB and cTnⅠ levels,LVDD,and LVDS(r=-0.498,-0.617,-0.506,-0.534,allP＜0.05).Serum NT-proBNP and CysC levels were negatively correlated with LVEF(r=-0.653,-0.607),but they were positively correlated with serum CK-MB and cTnI levels,LVDD,and LVDS(r=0.582,0.526,0.712,0.565,0.631,0.578,0.659,0.635,all P＜0.05).Conclusion Serum Nesfatin-1 levels decrease,while serum NT-proBNP and CysC levels increase in patients with acute STEMI.Serum Nesfatin-1,NT-proBNP,and CysC levels are closely related to myocardial enzymes and cardiac function.
ST elevation myocardial infarctionNatriuretic peptide,brainCreatine kinase,MB formTroponinHeart function testsUltrasonography,doppler,colorFeeding inhibition factor 1Cystatin C
NETL
NSTL
维普
万方数据
