Objective To investigate the clinical significance of the combined use of fine needle aspiration cytology(FNAC)and BRAFV600E gene mutation detection in the preoperative diagnosis of thyroid nodules.Methods A retrospective analysis was conducted on 126 cases of thyroid nodules confirmed by routine histopathology after surgery at Wenzhou Central Hospital between January 2022 and January 2023.The results of preoperative FNAC combined with BRAFV600E gene mutation detection were compared with those obtained from FNAC alone.Results There was no significant difference in specificity for thyroid nodules between FNAC combined with BRAFV600E gene mutation detection and FNAC alone(P＞0.05).The sensitivity of FNAC combined with BRAFV600E gene mutation detection was significantly higher than that of FNAC alone[97.6％(82/84)vs.85.5％(65/76),x2=7.82,P＜0.05].The overall accuracy of FNAC combined with BRAFV600E gene mutation detection was significantly higher than that of FNAC alone[96.8％(122/126)vs.85.0％(96/113),x2=10.47,P＜0.05].Conclusion The combined application of FNAC and BRAFV600E gene mutation detection holds an exceptional diagnostic value in the preoperative diagnosis of thyroid nodules.This approach not only elevates diagnostic sensitivity and accuracy,but also deserves clinical promotion.
Thyroid noduleCarcinoma,papillaryPathologySuctionCytological techniquesSensitivity and specificityProtein-serine-threonine kinases
NETL
NSTL
万方数据
