摘要
目的 分析拉萨市城关区3～16周岁儿童青少年身高发育的影响因素.方法 采用便利抽样法选取2021年8月至2022年6月拉萨市城关区3～16周岁儿童青少年100例为研究对象,收集受试者身体测量指标、Tanner分期、身高发育影响因素调查表、腕关节骨龄、性激素、营养生化指标等,采用单因素和多因素logistic回归分析身高发育的影响因素,并对影响因素绘制受试者工作特征(ROC)曲线.结果 该研究共纳入100例儿童青少年,其中高身材组受试者51例(51.0％),低身材组受试者49例(49.0％),两组间与全国平均身高差值、体质量、腰围、黄体生成素(LH)、黄体生成素水平(LH水平)、卵泡刺激素(FSH)、骨龄比较差异均有统计学意义[x2(t)=13.6、2.65、2.47、-2.58、10.9、-2.95、11.8,均P＜0.05];单因素logistic回归分析显示,体质量、腰围、LH水平、FSH、骨龄是身高发育的可能影响因素(OR=1.05、1.05、4.56、1.18、2.99,均P＜0.05);多因素logistic回归分析显示,腰围、LH水平、骨龄是影响身高发育的独立因素(OR=1.10、7.01、3.14,均P＜0.05).采用ROC曲线分析腰围、LH水平、骨龄及三者联合对该地区儿童青少年身高发育的预测价值(AUC=0,65、0.65、0.67、0.75,均P＜0.05).结论 腰围、LH水平、骨龄可能是影响拉萨市城关区儿童青少年身高发育的关键因素.
Abstract
Objective To analyze the factors that influence the height development of children and adolescents aged 3 to 16 years in Chengguan District of Lhasa of Xizang Autonomous Region,China.Methods During the period from August 2021 to June 2022,a convenient sampling method was used to select 100 children and adolescents aged 3-16 years residing in Chengguan District of Lhasa of Xizang Autonomous Region,China.The subjects'physical measurement indicators,Tanner stage,height development questionnaire,wrist bone age,sex hormones,and nutritional biochemical indicators were carefully collected.The factors that influence height development were analyzed using univariate and multivariate logistic regression analyses.Furthermore,the receiver operating characteristic(ROC)curves were constructed to visualize the effects of these influential factors.Results The study involved a total of 100 children and adolescents,with 51(51.0％)participants in the tall stature group and 49(49.0％)participants in the low stature group.Significant differences were observed between the two groups in terms of height difference relative to the national average,body weight,waist circumference,luteinizing hormone level,the percentage of individuals with an abnormal luteinizing hormone level,follicle stimulating hormone level,and bone age[x2(t)=13.6,2.65,2.47,-2.58,10.9,-2.95,11.8,all P＜0.05].A univariate logistic regression analysis revealed that body mass,waist circumference,the percentage of individuals with an abnormal luteinizing hormone level,follicle stimulating hormone level,and bone age are factors that possibly affect height development(OR=1.05,1.05,4.56,1.18,2.99,all P＜0.05).Furthermore,a multivariate logistic regression analysis revealed waist circumference,the percentage of individuals with an abnormal luteinizing hormone level,and bone age as independent factors influencing height development(OR=1.10,7.01,3.14,all P＜0.05).The receiver operating characteristic(ROC)curve analysis showed that the values of the area under the curve were 0.65,0.65,0.67,and 0.75 respectively for waist circumference,the percentage of individuals with an abnormal luteinizing hormone level,bone age,and their combination(all P＜0.05).Conclusion Waist circumference,the percentage of individuals with an abnormal luteinizing hormone level,and bone age appear to be critical factors influencing the height development of children and adolescents In Chengguan District of Lhasa of Xizang Autonomous Region,China.
基金项目
新疆维吾尔自治区自然科学基金(XZ202001ZR0072G)
NETL
NSTL
万方数据