糖尿病肾病与性激素关系的研究进展
Research progress of the relationship between diabetic nephropathy and sex hormones
张明雪 1郑仁东1
作者信息
- 1. 南京中医药大学附属中西医结合医院江苏省中医药研究院内分泌科,南京 210028
- 折叠
摘要
糖尿病肾病是糖尿病最常见、危害最大的微血管并发症之一.近年来,由于其发病率高、难以控制、预后较差,逐渐成为终末期肾病的主要原因.研究表明,糖尿病肾病患者体内性激素如睾酮、脱氢表雄酮、雌二醇、性激素结合球蛋白、促性腺激素水平出现失衡,反之,性激素水平失衡也会影响糖尿病肾病的进展.阐明性激素与糖尿病肾病之间可能存在的关系及相互作用,对糖尿病肾病的防治存在关键作用,值得进一步研究和思考.
Abstract
Diabetic nephropathy is one of the most common and harmful microvascular complications of diabetes.In recent years,it has become a leading cause of end-stage renal disease due to its high incidence rate,challenging control,and poor prognosis.Studies have revealed that patients with diabetic nephropathy often exhibit imbalanced levels of sex hormones such as testosterone,dehydroepiandrosterone,estradiol,sex hormone binding globulin,and gonadotropin.Conversely,the imbalance of sex hormones can also influence the progression of diabetic nephropathy.Therefore,clarifying the potential relationship and interaction between sex hormones and diabetic nephropathy is essential for effective prevention and treatment of diabetic nephropathy.This warrants further research and consideration.
关键词
糖尿病肾病/睾酮/硫酸脱氢表雄酮/雌二醇/性激素结合球蛋白/综述Key words
Diabetic nephropathies/Testosterone/Dehydroepiandrosterone sulfate/Estradiol/Sex hormone-binding globulin/Review引用本文复制引用
基金项目
国家中医药局西医学习中医优秀人才研修项目(国中医药人教发[2019]13号)
江苏省南京市中医药科技专项(ZYYB202227)
出版年
2024
NETL
NSTL
万方数据