Objective To analyze the risk factors for frailty in older adult patients with chronic obstructive pulmonary disease(COPD)and its correlation with oxidative stress.Methods A total of 168 patients with COPD aged 60 years and above,who were treated at Pingxiang People's Hospital from August 2022 to August 2023,were selected as the study subjects using the convenient sampling method.The FRAIL scale was utilized to assess frailty status.Patients were divided into two groups based on their FRAIL scale scores:the frail group(≥ 3 points,n=109),the non-frail/pre-frail group(＜3 points,n=59).Patients in the non-frail/pre-frail group were sub-divided into the pre-frail group(1-2 points,n=23),and the non-frail group(0 points,n=36).Serum levels of 8-hydroxydeoxyguanosine and malondialdehyde,and total antioxidant capacity were measured.One-way analysis of variance was performed to compare differences between groups,and correlation analysis was conducted.Logistic regression was used to identify the risk factors for frailty.Results The incidence of frailty among 168 older adult patients with COPD was 64.9％(109/168).Multivariable logistic regression analysis revealed that age(OR=1.59,95％CI 1.02-2.25),body mass index(OR=4.11,95％CI 2.02-8.42),comorbidities(OR=2.57,95％CI 1.31-5.02),activities of daily living(OR=3.07,95％CI 1.54-6.06),malnutrition(OR=2.97,95％CI 1.56-5.41),and cognitive impairment(OR=2.87,95％CI 1.42-5.88)were risk factors for frailty in older patients with COPD(P＜0.05).The frailty scores of older adult patients with COPD were significantly positively correlated with serum levels of 8-hydroxydeoxyguanosine and malondialdehyde(γ=0.67,0.65,P=0.008,0.006),and negatively correlated with total antioxidant capacity( γ=-0.54,P=0.012).Conclusion Age,body mass index,comorbidities,activities of daily living,malnutrition,and cognitive impairment are risk factors for frailty in older adult patients with COPD,and the severity of frailty is markedly associated with levels of oxidative stress products.
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