Objective To investigate the correlation between fibrinogen(FIB)/albumin(ALB)ratio(FAR)and active systemic lupus erythematosus(SLE),and its predictive value for prognosis.Methods Sixty-seven patients with active SLE who underwent outpatient and inpatient treatment at The First People's Hospital of Huzhou from January 2020 to October 2023 were included in this study.Another 36 patients with stable SLE who concurrently received treatment were chosen for a cohort study.Sex,age,duration of the disease,SLE disease activity index score,aspartate aminotransferase,alanine transaminase,lactate dehydrogenase,serum α-hydroxybutyrate dehydrogenase,triglycerides,total cholesterol,FIB,ALB,complement C3,complement C4,immunoglobulins,urinary trace ALB,creatinine,and other relevant data were statistically analyzed.Additionally,the predictive value of FAR for a poor prognosis in SLE was analyzed through regular telephone follow-ups after discharge.Results SLE disease activity index score,lactate dehydrogenase,α-hydroxybutyrate dehydrogenase,triglycerides,FIB,FAR,and urinary microalbumin/creatinine were all higher in active SLE patients than stable phase patients[(13.64±4.49)scores vs.(2.80±1.60)scores,(269.37±85.02)U/L vs.(158.53±64.10)U/L,(186.44±35.76)U/L vs.(163.72±30.94)U/L,(2.87±0.71)mmol/L vs.(2.48±0.68)mmol/L,(3 846.92±972.57)mg/L vs.(2 958.63±991.43)mg/L,(91.77±22.07)mg/g vs.(75.30±11.63)mg/g,(52.97±29.30)mg/g vs.(33.89±20.26)mg/g],while ALB and complement C3 were lower in active SLE patients than stable phase patients[(38.42±4.58)g/L vs.(41.11±4.26)g/L,(0.61±0.22)g/L vs.(0.79±0.28)g/L],and the differences were statistically significant(t=-13.96,6.84,-3.21,-2.69,-4.39,-4.17,-3.48,2.91,3.42,all P＜0.05).Before correcting for confounding factors,FIB,ALB,and FAR were all influencing factors for active SLE,with odds ratio values of 1.001,0.808,and 1.053,respectively.After correcting for confounding factors,FIB and FAR remained influencing factors for active SLE,with odds ratio values of 1.001 and 1.050,respectively.The area under the receiver operating characteristic curve of FIB,ALB,and FAR for predicting active SLE were 0.707,0.699,and 0.769,respectively,while the predictive value of FAR for active SLE was significantly higher than that of FIB and ALB(P＜0.05).The correlation coefficients(r)between FAR,FIB,ALB and SLE disease activity index were 0.405,0.389,and-0.319,respectively.The area under the receiver operating characteristic curve of FAR for predicting poor prognosis of active SLE was 0.734(0.614-0.853),with an optimal cutoff value of 97.50 mg/g.Conclusions FAR has a high predictive value for active SLE and poor prognosis SLE,and it is an influencing factor for active SLE.
Lupus erythematosus,systemicFibrinogenAlbuminsPrognosisRoot cause analysis
NETL
NSTL
万方数据
