Objective To compare the influence of dronedarone and amiodarone on the bleeding risk of patients with atrial fibrillation treated with rivaroxaban anticoagulation.Methods Clinical data of 81 patients with atrial fibrillation treated with rivaroxaban anticoagulation at Xi'an International Medical Center Hospital from January 2020 to July 2023,including 36 patients treated with dronedarone and 45 patients treated with amiodarone,were retrospectively analyzed.The effects of dronedarone and amiodarone on the anticoagulation of rivaroxaban were compared using the incidence of bleeding events,thrombosis events,and adverse reactions as outcome measures.Results The total bleeding in the dronedarone group[22.22％(8/36)]was significantly higher than that in the amiodarone group[6.67％(3/45)](x2=4.12,P＜0.05).The total bleeding of conventional-dose rivaroxaban in the dronedarone group was 30.00％(6/20),while the total bleeding of low-dose rivaroxaban was 12.50％(2/16),with no statistical significance(x2=1.58,P＞0.05).No thrombotic events or adverse reactions to dronedarone or amiodarone were observed in all patients.Conclusion Compared with amiodarone,dronedarone significantly increases the bleeding risk of rivaroxaban anticoagulation in patients with non-valvular atrial fibrillation,and reducing the dose of rivaroxaban in patients using dronedarone does not reduce the bleeding risk.
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