Effect of vitamin D3 supplementation in combination with adefovir dipivoxil and lamivudine on liver fibrosis indicators and cellular immunity in patients with hepatitis B cirrhosis
Objective To analyze the effect of vitamin D3 supplementation in combination with adefovir dipivoxil and lamivudine on liver fibrosis indicators and cellular immunity in patients with hepatitis B cirrhosis.Methods A total of 150 patients with hepatitis B cirrhosis who received treatment at The First Hospital of Yulin from February 2021 to April 2023 were included in this study.They were randomly divided into two groups using the random number table method,with 75 patients in each group.Both groups received treatment with adefovir dipivoxil and lamivudine,but the observation group also received vitamin D3 supplementation.Before and after treatment,liver function indicators,liver fibrosis indicators,and cellular immunity were measured and compared between the two groups to evaluate the efficacy of the treatments.Adverse reactions such as gastrointestinal bleeding,hypophosphatemia,and headache were observed.Results After treatment,alanine aminotransferase and aspartate aminotransferase levels in the observation group were significantly lower compared with the control group[(30.81±3.24)U/L vs.(39.82±4.07)U/L,(31.78±3.19)U/L vs.(37.96±3.89)U/L,t=15.00,10.64,both P＜0.001].After treatment,the levels of serum hyaluronic acid and laminin in the observation group were significantly lower than those in the control group(t=4.13,8.45,both P＜0.001).After treatment,the levels of CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group,while the level of CD8+was significantly lower(t=6.32,14.10,8.10,all P＜0.001).The total response rate in the observation group was significantly higher than that in the control group[89.33％(67/75)vs.70.67％(53/75),x2=8.17,P＜0.05].There was no statistically significant difference in the total incidence of adverse reactions such as gastrointestinal bleeding and headache between the control and observation groups(x2=0.32,P＞0.05).Conclusion Vitamin D3 supplementation in combination with adefovir dipivoxil and lamivudine is remarkably effective in the treatment of hepatitis B cirrhosis.The combined therapy can efficiently correct cellular immune disorders in patients,mitigate liver fibrosis,enhance liver function,and is considered highly safe.
Hepatitis BLiver cirrhosisAlanine transaminaseT-lymphocyte subsetsDrug-related side effects and adverse reactionsImmunity,cellular
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