Objective To investigate the value of serum brain natriuretic peptide(BNP)and homocysteine(Hcy)in the clinical diagnosis and treatment of acute cerebral infarction.Methods This is a case-control study.A total of 205 patients with acute cerebral infarction admitted to Central Hospital of Xinyu Iron & Steel Group Co.,Ltd.from January 2021 to June 2022 were included in the patient group.These patients were further divided into mild(n=98),moderate(n=69),and severe(n=38)subgroups based on their National Institutes of Health Stroke Scale scores.Additionally,120 healthy individuals who underwent concurrent physical examinations were included in the healthy group.Fasting venous blood samples were collected from all participants.The serum levels of BNP and Hcy were determined,and the serum levels of Hcy and BNP in the various neurological deficit subgroups of the patient group were compared.Based on the modified Rankin Scale score,the patients were categorized into a good prognosis group(mRS score ≤ 2,n=142)and a poor prognosis group(mRS score＞2,n=63).The serum levels of Hcy and BNP were then compared between patients with different prognoses.Pearson correlation analysis was performed to assess the association between BNP and Hcy levels and the prognostic score in the patient group.Results The serum levels of Hcy and BNP in the patient group were(17.21±2.67)μmol/L and(279.56±47.40)ng/L,respectively,which were significantly higher than the(6.68±1.04)μmol/L and(57.38±8.56)ng/L in the healthy group(t=-41.38,-50.83,both P＜0.001).The serum levels of Hcy and BNP in the severe subgroup were(25.87±5.25)μmol/L and(420.19±94.36)ng/L,respectively,and they were(17.63±3.95)μmol/L and(295.56±56.27)ng/L in the moderate subgroup,and(12.35±2.24)μmol/L and(182.82±35.64)ng/L,respectively,in the mild subgroup.Significant differences in serum levels of Hcy and BNP were observed among the mild,moderate,and severe subgroups(F=197.54,248.20,all P＜0.001).The serum levels of Hcy and BNP in the poor prognosis group were(22.36±4.17)μmol/L and(365.19±54.82)ng/L,respectively,which were significantly higher than those in the good prognosis group(t=12.35,18.40,both P＜0.001).Correlation analysis revealed that both serum BNP and Hcy levels were positively correlated with their modified Rankin Scale prognostic scores in the patient group(r=0.796,0.780,both P＜0.001).Conclusion The serum levels of Hcy and BNP in patients with acute cerebral infarction can effectively assess the severity of the disease and can also serve as a valuable reference in predicting prognosis.
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