摘要
目的 观察蓣鹿生精方联合左卡尼汀治疗脾肾亏虚型少弱精子症的临床效果及其对中医症候积分、精子活力的影响.方法 采用随机对照研究,选取安徽中医药大学附属淮北市中医医院2022年3月至2023年12月接诊的脾肾亏虚型少弱精症患者64例,根据随机数字表法分为观察组33例、对照组31例.对照组予左卡尼汀治疗,观察组给予蓣鹿生精方联合左卡尼汀治疗,治疗3个月后比较两组临床疗效、治疗前后中医症候积分及精液指标[精液量、精子浓度、前向运动精子(PR)、PR+非前向运动精子(NP)]的变化.结果 观察组总有效率为84.85％(28/33),高于对照组的61.29％(19/31),差异有统计学意义(x2=4.55,P＜0.05).治疗后,观察组主症积分、次症积分分别为(1.64±1.20)分、(1.27±0.84)分,均低于对照组的(1.82±1.04)分、(2.19±0.87)分,差异均有统计学意义(t=-2.94、-4.30,均P＜0.05);观察组精液量、精子浓度、PR、PR+NP分别为(4.07±0.86)mL、(28.81±6.48)× 106/mL、(30.82±11.43)％、(70.69±13.60)％,均高于对照组的(3.62±0.73)mL、(23.87±11.38)×106/mL、(24.31±8.27)％、(63.11±14.28)％(t=2.14、2.02、2.47、2.05,均P＜0.05).结论 蓣鹿生精方联合左卡尼汀治疗脾肾亏虚型男性少弱精症效果显著,能有效改善患者中医症候,提高患者精液质量和精子活力.
Abstract
Objective To investigate the clinical efficacy of combined use of Yulu Shengjing Decoction and Levocarnitine in the treatment of oligoasthenozoospermia resulting from spleen and kidney deficiency and its effect on traditional Chinese medicine syndrome score and sperm motility.Methods A randomized controlled study was conducted on 64 patients with oligoasthenozoospermia resulting from spleen and kidney deficiency who received treatment at the Huaibei Hospital of Traditional Chinese Medicine,Anhui University of Chinese Medicine between March 2022 and December 2023.These patients were randomly divided into an observation group(n=33)and a control group(n=31)using a random number table method.The control group received treatment with Levocarnitine,while the observation group received treatment with a combination of Yulu Shengjing Decoction and Levocarnitine.After 3 months of treatment,the clinical efficacy of the two groups was compared.The relative changes in traditional Chinese medicine syndrome scores and semen indicators(including semen volume,sperm concentration,progressive motility,and progressive motility+non-progressive motility)were evaluated after treatment compared with their respective pre-treatment levels.Results The total response rate in the observation group was 84.85％(28/33),which was significantly higher than that in the control group[61.29％(19/31),x2=4.55,P＜0.05].After treatment,the main symptom score and secondary symptom score of the observation group were(1.64±1.20)points and(1.27±0.84)points,respectively,which were significantly lower than(1.82±1.04)points and(2.19±0.87)points in the control group(t=-2.94,-4.30,both P＜0.05).The semen volume,sperm concentration,progressive motility,and progressive motility+non-progressive motility of the observation group were(4.07±0.86)mL,(28.81±6.48)×106/mL,(30.82±11.43)％,and(70.69±13.60)％,respectively.These values were significantly higher than those in the control group[(3.62±0.73)mL,(23.87±11.38)×106/mL,(24.31±8.27)％,(63.11±14.28)％,t=2.14,2.02,2.47,2.05,all P＜0.05).Conclusion The combination of Yulu Shengjing Decoction and Levocarnitine is effective in treating oligoasthenozoospermia with spleen and kidney deficiency.It can significantly improve patients'symptoms in traditional Chinese medicine,enhance semen quality,and increase sperm motility.
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