硼替佐米诱发周围神经病变发病机制的研究进展
Research progress in the pathogenesis of bortezomib-induced peripheral neuropathy
邹娇 1黄迷迷 1宋丽霞 1佟长青2
作者信息
- 1. 河北北方学院研究生院,张家口 075000
- 2. 河北北方学院附属第一医院血液病科,张家口 075000
- 折叠
摘要
硼替佐米可通过多种机制可逆地抑制蛋白酶体发挥其抗骨髓瘤作用,是我国目前治疗多发性骨髓瘤的一线药物.硼替佐米诱发的周围神经病变(bortezomib-induced peripheral neuropathy,BIPN)是多发性骨髓瘤患者治疗过程中最常见、最令人担忧的剂量限制性不良反应之一,可严重影响患者的生活质量,导致减药甚至停药.如何减少或预防BIPN的发生是多发性骨髓瘤治疗过程中的难题.基于此,该研究从施万细胞、神经元、星形胶质细胞等方面综述了 BIPN的发病机制.
Abstract
Bortezomib exerts its anti-myeloma effect by reversibly inhibiting the proteasome through various mechanisms,and it is currently the first-line drug for the treatment of multiple myeloma in China.Bortezomib-induced peripheral neuropathy is one of the most common dose-limiting adverse reactions in the treatment process,which seriously affects the quality of life of patients,leading to dose reduction or even drug withdrawal.How to reduce or prevent Bortezomib-induced peripheral neuropathy remains a challenging problem in the treatment of multiple myeloma.Based on this,this article reviews the pathogenesis of Bortezomib-induced peripheral neuropathy from the perspectives of Schwann cells,neurons,astrocytes,macrophages,and other aspects.
关键词
硼替佐米/周围神经/多发性骨髓瘤/神经元/星形细胞/综述Key words
Bortezomib/Peripheral nerves/Multiple myeloma/Neurons/Astrocytes/Review引用本文复制引用
出版年
2024
NETL
NSTL
万方数据