Objective To analyze the effect of optical zone diameter in orthokeratology contact lenses on the efficacy of treatment.Methods A total of 100 myopic patients(196 eyes)who wore Paragon CRT keratoplasty lenses with a diameter of 10.5 mm were retrospectively included in this study.These patients,consisting of 47 males and 53 females,were admitted to The Affiliated Hospital of Hangzhou Normal University between November 2020 and November 2022.Their ages ranged from 8 to 13 years.Their refractive errors ranged from-0.75 DS to-4.00 DS for spherical errors and from-0.25 DC to-1.50 DC for cylindrical errors.The corrected visual acuity was ≥ 0.6,and the initial axes were between 23.40 mm and 25.83 mm.The patients were grouped according to the different diameters of the optical zones of their lenses.Fifty patients(98 eyes)with an optical zone of 5.0 mm were included in the 5.0 group,and another 50 patients(98 eyes)with an optical zone of 6.0 mm were included in the 6.0 group.The general sociological and disease-related characteristics of the two groups were recorded.Logistic linear regression analysis was performed on the data with differences to obtain the therapeutic effect of different optimal zone diameters in orthokeratology contact lenses.Results After 1 year of wearing,there was no statistically significant difference in the average non-invasive tear film break-up time between the two groups(P＞0.05).The 5.0 group exhibited significantly lower values for the surface regularity index(0.35±0.09),surface asymmetry index(0.69±0.21),axial length[(0.19±0.04)mm],and relative peripheral refraction[(-0.65±0.20)D,(-0.84±0.26)D,(-0.48±0.13)D,(-0.76±0.23)D,(-0.77±0.21)D,(-0.56±0.17)D]compared with the 6.0 group(t=5.94,3.34,4.64,2.03,2.07,4.23,2.27,2.25,5.55,all P＜0.05).Conversely,the uncorrected visual acuity[(0.71±0.20)LogMAR]and spherical equivalent[(-0.25±0.05)D]were significantly higher in the 5.0 group compared with the 6.0 group(t=3.31,13.64,both P＜0.05).After 1 year of wearing,the diameter and area of the optical zone in the 5.0 group[(3.35±0.28)mm and(7.50±1.10)mm2]were significantly lower than those in the 6.0 group[(3.68±0.38)mm and(8.50±1.50)mm2,t=6.92,5.32,11.16,all P＜0.05].Furthermore,the overlapping treatment zone area to pupil area ratio(TZR)in the 5.0 group(0.53±0.16)was significantly lower than that in the 6.0 group[(0.81±0.19),t=11.16,P＜0.05].The results of logistic linear regression analysis and Pearson calculation showed that the TZR was positively correlated with the optical zone diameters of orthokeratology contact lenses(P＜0.05).There was no significant difference in the incidence of complications between the 5.0 group[8.16％(8/98)]and the 6.0 group[12.24％(12/98),x2=0.89,P＞0.05).Conclusion The 1-year dynamic change in eye axis indicates that myopia correction is more effective and safe when the diameter of the optical zone in keratoplasty is 5.0 mm compared with when the diameter of the optical zone is 6.0 mm.Evaluating the efficacy of corneal reshaping lenses in different optical zones using statistical TZR can guarantee myopia control results.At the same time,this study demonstrates significant innovation and scientific validity,which can offer new ideas and methods for the research and application of orthokeratology contact lenses.
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