With the development of the times and the continuous advancement of medical technology,oxygen therapy has become an indispensable part of clinical diagnosis and treatment,serving as the fundamental form of care provided to patients.High-flow nasal cannula oxygen therapy is able to exert an end-expiratory pressure effect,provide heating and humidification,and continuously flush the physiologically ineffective cavity of the nasopharyngeal area.Additionally,due to its comfort,high-flow nasal cannula oxygen therapy has replaced ordinary oxygen therapy and some forms of noninvasive ventilation in clinical settings,becoming the preferred choice for clinical treatment.High-flow nasal cannula oxygen therapy is widely utilized in clinical practice due to its unique physiological effects.Obstructive sleep apnea hypopnea syndrome is a common sleep disorder that leads to disrupted sleep patterns,recurrent occurrence of suffocation and wakefulness,and increased morbidity and mortality of cardiovascular diseases.Therefore,it is crucial to initiate scientific and effective treatments promptly.High-flow nasal cannula oxygen therapy not only provides a high-flow airflow and corresponding airway pressure,but also has a high level of tolerability,making it gradually adopted in the treatment of patients with obstructive sleep apnea hypopnea syndrome.In this review,we investigate the physiological effects of high-flow nasal cannula oxygen therapy and its application in obstructive sleep apnea hypopnea syndrome,with the objective of providing a theoretical basis for scholars working in the same field.