Objective To investigate the clinical efficacy of ciprofol in modified electroconvulsive therapy for the treatment of major depressive disorder in patients.Methods A total of 60 patients with major depressive disorder who received modified electroconvulsive therapy at the Department of Psychiatry,First Hospital of Shanxi Medical University,from November 2022 to March 2023 were included in this study.They were aged 18-60 years and classified as American Society of Anesthesiologists grades Ⅰ-Ⅱ.The patient cohort consisted of 31 males and 29 females,with a body mass index of 18-30 kg/m2.The disease duration varied from 3 months to 5 years.This study was designed as a prospective study.All included patients were assigned to observation(ciprofol+succinylcholine)and control(propofol+succinylcholine)using the digital number table method.Vital signs,including heart rate,mean arterial pressure,and blood oxygen saturation,were compared between the two groups at four time points:before anesthesia(T0),after anesthesia(T1),immediately after electroconvulsive therapy(T2),and after the completion of electroconvulsive therapy(T3).The time to recover spontaneous breathing(from intravenous injection of succinylcholine to the onset of spontaneous breathing),the time to recover consciousness(from intravenous injection of ciprofol/propofol to the onset of consciousness),the need for additional anesthetic drugs,the use of vasoactive medications,and the occurrence of adverse reactions were recorded in each group.Results Compared with T0,both groups exhibited a decrease in mean arterial pressure at T1 and an increase at T2 and T3.The differences in mean arterial pressure between T1,T2,T3,and T0 were statistically significant[observation group:T0:(84.11±8.69)mmHg(1 mmHg=0.133 kPa),T1:(78.18±8.39)mmHg,T2:(99.28±12.42)mmHg,T3:(87.31±8.66)mmHg;control group:T0:(86.33±10.99)mmHg,T1:(75.93±9.51)mmHg,T2:(100±13.3)mmHg,T3:(93.47±12.27)mmHg,all P＜0.05].There was no statistically significant difference in heart rate at different time points between the two groups(all P＞0.05).The change in mean arterial pressure from T0 to T1 in the observation group was smaller than that in the control group during the same period.The change in mean arterial pressure from T2 to T3 in the control group was smaller compared with that in the observation group.The time to recover consciousness in the observation group was significantly shorter than that in the control group[observation group:(8.76±0.59)minutes,control group:(9.4±0.64)minutes,t=-4.07,P＜0.05].The incidence of injection pain in the observation group was significantly lower than that in the control group[observation group:0,control group:30.00％(9/30),x2=8.36,P＜0.05].There were no statistically significant differences in time to recover spontaneous breathing,the number(percentage)of patients experiencing headaches,hypotension,increased secretions,or postoperative nausea and vomiting,or the number(percentage)of patients using vasoactive drugs between the two groups(all P＞0.05).Conclusion When used in modified electroconvulsive therapy,ciprofol can provide excellent anesthetic effects.It results in more stable hemodynamics in patients,causes milder injection pain,and leads to a faster recovery compared with propofol.
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