Effect of high-frequency repetitive transcranial magnetic stimulation combined with sertraline on depressive symptoms and self-injurious behaviors in adolescents with depression and nonsuicidal self-injury
Objective To investigate the effect of high-frequency repetitive transcranial magnetic stimulation combined with sertraline on depressive symptoms and self-injurious behaviors in adolescents with depression and non-suicidal self-injury.Methods This study was a prospective study.A total of 112 adolescent patients with depression and non-suicidal self-injury who received treatment at the Third Hospital of Quzhou from January 2021 to September 2023 were included in this study.These patients were divided into a control group and a study group,with 56 patients per group,using the random digital table method.The control group was treated with sertraline,while the study group was treated with high-frequency repetitive transcranial magnetic stimulation combined with sertraline.The depression scores[assessed using the 24-item Hamilton Depression Scale(HAMD-24)and the Self-Rating Depression Scale(SDS)],self-injury status,and inflammatory factor levels(tumor necrosis factor-α,interleukin-10,and interleukin-1β levels)were compared before and after the intervention.Results Before intervention,there were no statistically significant differences in HAMD-24 scores and SDS scores between the two groups(both P＞0.05).After intervention,both HAMD-24 scores and SDS scores decreased significantly in both groups(both P＜0.05).Additionally,the HAMD-24 scores[(13.46±3.98)points]and SDS scores[(50.28±5.13)points]in the study group were significantly lower than those in the control group[(19.89±4.23)points,(71.62±6.88)points,t=-8.28,-18.61,both P＜0.05].Before intervention,there were no statistically significant differences in the number of self-injury incidents and self-injurious behavior scores between the two groups(both P＞0.05).After intervention,the number of self-injury incidents and the score of self-injurious behaviors significantly decreased in the study group compared with before intervention(both P＜0.05).After intervention,the number of self-injury incidents in the control group was decreased compared with before intervention(P＜0.05),while the score of self-injurious behaviors did not differ significantly compared with before intervention(P＞0.05).After intervention,the number of self-injury incidents[(2.15±1.06)times]and the score of self-injurious behaviors[(2.41±0.65)points]in the study group were significantly lower than those in the control group[5.43±3.61)times,(12.04±3.01)points,t=-7.78,-23.40,both P＜0.05].Before intervention,there were no statistically significant differences in interleukin-1β,tumor necrosis factor-α,and interleukin-10 levels between the two groups(all P＞0.05).After intervention,interleukin-1β and tumor necrosis factor-α levels in the study group were significantly lower than those before intervention(both P＜0.05),while interleukin-10 levels in the study group were significantly higher than those before intervention(P＜0.05).There were no statistically significant differences in the levels of interleukin-1β,tumor necrosis factor-α,and interleukin-10 between the pre-and post-intervention measurements in the control group(all P＞0.05).After intervention,interleukin-1β levels[(57.15±6.33)ng/L]and tumor necrosis factor-αlevels[(13.87±5.91)ng/L]in the study group were significantly lower than those in the control group[(73.61±8.52)ng/L,(17.12±5.28)ng/L],while interleukin-10 levels[(1.62±0.66)ng/L]were significantly higher than those in the control group[(1.19±0.63)ng/L,t=-11.60,3.53,-3.07,all P＜0.05].Conclusion High-frequency repetitive transcranial magnetic stimulation combined with sertraline can significantly reduce depressive symptoms and self-injurious behaviors in adolescents with depression and non-suicidal self-injury.The reason may be due to the decrease in inflammatory factor levels in patients.
Depressive DisorderTranscranial magnetic stimulationSertralineSelf-injurious behaviorAdolescents
NETL
NSTL
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