Objective To investigate the clinical characteristics in older adult patients with sepsis and heart failure,and to analyze the influential factors of prognosis.Methods Eighty-eight older adult patients with sepsis and heart failure who received treatment at Lishui Central Hospital from January 2020 to December 2022 were retrospectively included in the heart failure group.Eighty-eight older adult patients with sepsis,who did not have heart failure,were selected in a 1∶1 ratio to form a non-heart failure group.Based on their survival status during hospitalization,the patients in the heart failure group were divided into two subgroups:the survival group and the death group.Logistic regression analysis was performed to identify the risk factors associated with the development of heart failure and adverse disease outcomes in older adult patients with sepsis.Results There were no statistically significant differences in sex,smoking history,alcohol consumption history,history of hypertension,and history of diabetes between the heart failure group and the non-heart failure group(all P＞0.05).However,the proportion of patients aged 75 years or older in the heart failure group was 52.27％(46/88),which was significantly higher than the proportion in the non-heart failure group[34.09％(30/88),x2=5.93,P＜0.05].The proportion of patients with respiratory system infections in the heart failure group was 53.41％(47/88),which was significantly higher than the proportion in the non-heart failure group[29.55％(26/88),x2=10.37,P＜0.05].Logistic regression analysis showed that advanced age and respiratory system infections are independent risk factors for the development of heart failure in patients with sepsis.Among patients with sepsis and heart failure,45 survived and 43 died,resulting in a mortality rate of 48.86％.The average age of patients in the death group was(76.27±4.14)years,which was significantly higher than that in the survival group[(72.29±4.06)years,t=4.55,P＜0.05].The brain natriuretic peptide level and the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score in the death group were(636.70±70.29)pg/mL and(31.93±3.08)points,respectively,both of which were significantly higher than those in the survival group[(552.80±54.66)pg/mL,(27.06±3.80)points,t=6.27,6.59,both P＜0.05].The lactate clearance rate and serum albumin level in the death group were(13.63±4.84)％and(26.09±4.77)g/L,respectively,both of which were significantly lower than those in the survival group[(19.94±5.07)％,(30.55±5.17)g/L,t=5.97,4.20,both P＜0.05].Logistic regression analysis showed that in patients with sepsis and heart failure,advanced age,elevated serum brain natriuretic peptide levels,and high APACHE Ⅱ scores are risk factors for poor prognosis and death.A high lactate clearance rate at 24 hours and elevated serum albumin levels are protective factors for survival.Conclusion Advanced age and respiratory system infections increase the risk of heart failure in patients with sepsis.Advanced age,elevated brain natriuretic peptide levels,and high APACHE Ⅱ scores are associated with an increased risk of death in these patients.High lactate clearance rates and elevated serum albumin levels are indicative of a reduced risk of death in patients with sepsis.
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