Effect of high-frequency repetitive transcranial magnetic stimulation combined with fluvoxamine treatment on improving depression,impulsivity,and self-injury levels in adolescent patients with depression
Objective To investigate the effect of high-frequency repetitive transcranial magnetic stimulation combined with fluvoxamine treatment on improving depression,impulsivity,and self-injury levels in adolescent patients with depression.Methods A total of 124 adolescent patients with depression who received treatment at the Department of Psychiatry,The Third Hospital of Quzhou,China from January 2022 to November 2023 were included in this study.The patients were randomly divided into a control group and an observation group,with 62 patients per group,using the random number table method.Patients in the control group received treatment with fluvoxamine,while patients in the observation group underwent high-frequency repetitive transcranial magnetic stimulation and treatment with fluvoxamine.Clinical efficacy and the scores of the Hamilton Depression Scale,Hamilton Anxiety Scale,the Barratt Impulsiveness Scale-11 revised version,and the Non-Suicidal Self-Injury Assessment Tool revised version were compared between the two groups.Results The total response rate in the observation group was 90.32％(56/62),which was significantly higher than that in the control group[72.58％(45/62),x2=6.46,P＜0.05].After treatment,scores of the Hamilton Depression Scale and Hamilton Anxiety Scale in the observation group were(12.08±1.97)points and(11.58±1.59)points,respectively,which were significantly lower than those in the control group[(16.42±2.33)points,(14.42±1.94)points,t=-8.28,-18.61,both P＜0.05].After treatment,the scores of the Barratt Impulsiveness Scale-11 revised version and Non-Suicidal Self-Injury Assessment Tool revised version in the observation group were significantly lower than those in the control group[(28.25±3.91)points,(9.23±2.12)points,t=5.42,9.44,both P＜0.05].Conclusion High-frequency repetitive transcranial magnetic stimulation combined with fluvoxamine treatment can significantly reduce depressive symptoms,impulsivity,and self-injury levels in adolescent patients with depression.
Depressive disorderTranscranial magnetic stimulationAdolescentImpulsive behaviorSelf-injurious behaviorFluvoxamine
维普
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