Efficacy of alveolar lavage combined with montelukast in the treatment of acute exacerbations of chronic obstructive pulmonary disease and its effect on oxidative stress and inflammatory factors in patients
Objective To investigate the efficacy of alveolar lavage combined with montelukast in the treatment of acute exacerbations of chronic obstructive pulmonary disease(AECOPD)and its effect on oxidative stress and inflammatory factors in patients.Methods A prospective study was conducted involving 90 patients with AECOPD who were admitted to the Intensive Care Unit of Shan County Central Hospital from December 2021 to December 2022.The patients were randomly divided into a control group and an observation group,with 45 patients in each group,using the random number table method.The control group received conventional treatment,while the observation group was additionally treated with alveolar lavage combined with montelukast.Symptom score,Acute Physiology and Chronic Health Evaluation Ⅱ score,overall response rate,serum levels of oxidative stress markers(malondialdehyde,4-hydroxynonenal,and superoxide dismutase),and serum levels of inflammatory factors(C-reactive protein,tumor necrosis factor-α,interleukin-6,and procalcitonin)were compared between the two groups before and after treatment.Results After treatment,the symptom scores for both groups decreased significantly compared with their respective scores before treatment(t=6.68,11.32,both P＜0.05).After treatment,the symptom score in the observation group was significantly lower than that in the control group[(8.69±0.84)points vs.(15.39±1.18)points,t=8.75,P＜0.05].After treatment,the Acute Physiology and Chronic Health Evaluation Ⅱ score in the observation group was significantly lower than that in the control group(t=9.19,P＜0.05).The overall response rate in the observation group was significantly higher than that in the control group[93.33％(42/45)vs.75.56％(34/45),t=4.56,P＜0.05].After treatment,serum levels of 4-hydroxynonenal and malondialdehyde in the observation group were significantly lower than those in the control group(t=4.20,5.15,both P＜0.05),while serum level of superoxide dismutase in the observation group was significantly higher than that in the control group(t=5.23,P＜0.05).After treatment,serum levels of C-reactive protein,tumor necrosis factor-α,interleukin-6,and procalcitonin in the observation group were significantly lower than those in the control group(t=6.86,5.60,8.75,4.89,all P＜0.05).Conclusion Alveolar lavage combined with montelukast can reduce clinical symptoms in patients with AECOPD,promote recovery,enhances clinical efficacy,decreases oxidative stress responses,increases the body's antioxidant capacity,lowers the expression of inflammatory factors,and reduces inflammatory responses.
维普
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