Effects of blockade therapy using ornidazole combined with minocycline on periodontal indicators and inflammatory factor levels in gingival crevicular fluid of patients with chronic pulpitis
Objective To investigate the effects of blockade therapy using ornidazole combined with minocycline on periodontal indicators and inflammatory factor levels in gingival crevicular fluid of patients with chronic pulpitis.Methods A total of 82 patients with chronic pulpitis who received treatment at the Taian Stomatological Hospital from May 2021 to May 2023 were included in this study.The patients were randomly assigned to receive blockade therapy with either ornidazole combined with minocycline(n=41 patients,45 teeth,combined treatment group)or minocycline alone(n=41 patients,45 teeth,control group).Clinical efficacy was compared between the two groups.Additionally,changes in periodontal indexes(sulcus bleeding index and probing depth),levels of inflammatory factors in gingival crevicular fluid(tumor necrosis factor-αand C-reactive protein),and chewing function(bite force and chewing efficiency)were compared between the two groups before and after treatment.Complications,such as tooth pain and occlusal discomfort,were recorded.Results The total effective rate in the combined treatment group was significantly higher than that in the control group[95.56％(43/45)vs.80％(36/45),x2=5.08,P=0.024].After treatment,the probing depth and sulcus bleeding index in the combined treatment group were significantly lower than those in the control group[(1.89±0.22)mm vs.(3.09±0.42)mm,(0.81±0.09)points vs.(1.36±0.17)points,t=16.98,19.17,both P＜0.001].The levels of tumor necrosis factor-α and C-reactive protein in the combined treatment group were significantly lower than those in the control group[(1.24±0.21)μg/L vs.(2.10±0.31)μg/L,(4.14±0.51)mg/L vs.(6.05±0.71)mg/L,t=15.41,14.66,both P＜0.001].Additionally,the bite force and chewing efficiency in the combined treatment group were significantly higher than those in the control group[(132.85±13.79)lbs vs.(117.14±12.64)lbs,(90.16±9.34)％vs.(81.05±8.75)％,t=5.59,4.78,both P＜0.001].The total incidence rate of complications,such as occlusal discomfort and tooth pain,in the combined treatment group was significantly lower than that in the control group[4.44％(2/45)vs.17.78％(8/45),x2=4.05,P=0.044].Conclusion Ornidazole combined with minocycline for the treatment of chronic pulpitis can significantly improve periodontal conditions,reduce inflammatory responses,enhance masticatory function,and decrease the incidence of complications following root canal treatment.This combined therapy demonstrates a marked curative effect.
PulpitisPit and fissure sealantsPeriodontal indexBite forceTumor necrosis factor-alphaC-reactive proteinOrnidazoleMinocycline
维普
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