首页|脑卒中吞咽障碍患者营养不良风险预测模型的构建

脑卒中吞咽障碍患者营养不良风险预测模型的构建

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目的 探讨脑卒中吞咽障碍患者营养不良发生现状及其影响因素,构建营养不良预测模型并完成验证.方法 便利抽样法选取2019年1月至2023年12月温州市中心医院收治的脑卒中吞咽障碍患者150例为研究对象,通过查阅文献结合专家咨询的方法,确立影响因素:年龄、性别、身体质量指数(BMI)、吸烟史、饮酒史、住院次数、文化程度、巴塞尔指数(Barthel指数)、高血压、糖尿病史、冠心病、有无肢体障碍、血红蛋白、格拉斯哥昏迷指数(GCS)评分、美国国立卫生研究院卒中量表(NIHSS)评分,共15个影响因素,按是否发生营养不良,分为营养不良组和正常组,分析发生营养不良影响因素,利用回归分析构建营养不良风险预测模型,使用列线图展示模型并完成验证.结果 脑卒中吞咽障碍患者150例中,年龄(59.34±6.46)岁;女性83例,男性67例.其中,发生营养不良66例,发生率为 44.00%;年龄(x2=4.03,P=0.045)、BMI(t=6.33,P<0.001)、饮酒(x2=3.90,P=0.048)、住院次数(x2=9.45,P=0.024)、巴塞尔指数(x2=7.78,P=0.020)、有无肢体障碍(x2=4.64,P=0.031)、血红蛋白(x2=4.38,P=0.036)及GCS评分(x2=9.83,P=0.007)等成为脑卒中吞咽障碍患者营养不良的独立危险因素(均P<0.05).高龄、BMI<18.5 kg/m2、饮酒、住院次数>5次、Barthel指数<40分、肢体障碍、血红蛋白异常及GCS评分≤11分的脑卒中吞咽障碍患者更易发生营养不良(均P<0.05).预测营养不良发生的C-index为0.85 1,95%CI(0.809,0.892),约登指数最大值为0.562,灵敏度为84.1%,特异度为72.1%.结论 脑卒中吞咽障碍患者营养不良危险因素为高龄、饮酒、住院次数>5次、肢体障碍、血红蛋白异常,脑卒中吞咽障碍患者营养不良的保护性因素为BMI>23.9 kg/m2、Barthel指数>60分、GCS评分≥ 14分.采用预测模型对脑卒中吞咽障碍患者营养不良发生具有一定的预测价值.
Construction of a malnutrition risk prediction model for patients with stroke and dysphagia
Objective To investigate the current status of malnutrition and its influential factors among patients with stroke and dysphagia,and to develop and validate a malnutrition risk prediction model.Methods Using a convenience sampling method,150 patients with stroke and dysphagia admitted to Wenzhou Central Hospital from January 2019 to December 2023 were included in this study.Through a review of the literature and expert consultations,15 influential factors were identified:age,gender,body mass index(BMI),history of smoking alcohol consumption,number of hospitalizations,education level,Barthel index,history of hypertension,history of diabetes,coronary heart disease,presence of limb disabilities,hemoglobin levels,Glasgow Coma Scale(GCS)score,and National Institutes of Health Stroke Scale score.Patients were categorized into malnutrition and normal groups based on the occurrence of malnutrition.The influential factors for malnutrition were analyzed,and a malnutrition risk prediction model was constructed using regression analysis.The model was presented using a nomogram and subsequently validated.Results Among the 150 patients with stroke and dysphagia,the average age was(59.34±6.46)years,with 83 females and 67 males.Of these patients,66(44.00%)were found to be malnourished.The following factors were identified as independent risk factors for malnutrition in patients with stroke and dysphagia:age(x2=4.03,P=0.045),BMI(t=6.33,P<0.001),alcohol consumption(x2=3.90,P=0.048),number of hospitalizations(x2=9.45,P=0.024),Barthel index(x2=7.78,P=0.020),presence of limb disabilities(x2=4.64,P=0.031),hemoglobin levels(x2=4.38,P=0.036),and GCS score(x2=9.83,P=0.007)(all P<0.05).Patients who were older,had a BMI<18.5 kg/m2,consumed alcohol,had more than five hospitalizations,a Barthel index<40,limb disabilities,abnormal hemoglobin levels,or a GCS score ≤ 11 were more likely to experience malnutrition(all P<0.05).The C-index for predicting malnutrition was 0.851,with a 95%CI of(0.809,0.892).The maximum Youden index was 0.562,with a sensitivity of 84.1%and specificity of 72.1%.Conclusion The risk factors for malnutrition in patients with stroke and dysphagia include advanced age,alcohol consumption,more than five hospitalizations,limb disabilities,and abnormal hemoglobin levels.Protective factors against malnutrition in these patients are a BMI>23.9 kg/m2,a Barthel index>60,and a GCS score ≥ 14.The prediction model demonstrates a significant predictive value for the occurrence of malnutrition in patients with stroke and dysphagia.

Cerebrovascular disordersDeglutition disordersMalnutritionRisk factorsFactor analysis,statisticalNomogramsForecasting

杨晶晶、简静雯、陈凌英、胡娟娟

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温州市中心医院神经内科,温州 325000

脑血管障碍 吞咽障碍 营养不良 危险因素 因素分析,统计学 列线图 预测

浙江省温州市科研项目

Y20210663

2024

中国基层医药
中华医学会,安徽医科大学

中国基层医药

影响因子:1.003
ISSN:1008-6706
年,卷(期):2024.31(10)
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