Effects of roxadustat combined with erythropoietin on oxidative stress and nutritional indicators in patients with renal anemia undergoing hemodialysis
Objective To investigate the effect of roxadustat combined with erythropoietin on oxidative stress and nutritional indicators in patients with renal anemia undergoing hemodialysis.Methods Eighty-eight patients with renal anemia who were undergoing hemodialysis at Zhuji Central Hospital from September 2021 to September 2023 were included in this randomized controlled study.They were divided into an observation group and a control group,with 44 patients in each group,using the random number table method.The control group received erythropoietin treatment,while the observation group received treatment with roxadustat and erythropoietin.All patients were treated for 12 weeks.The efficacy of the two groups was observed,along with changes in iron metabolism,oxidative stress,nutritional indicators,and inflammatory factors before and after treatment.Results The overall effective rate in the observation group was 93.18％(41/44),which was significantly higher than the 72.73％(32/44)in the control group(x2=6.51,P＜0.05).After treatment,the serum iron saturation,total iron binding capacity,and serum iron levels in the observation group were(13.86±2.54)％,(46.54±4.81)μmol/L,and(263.07±28.84)μmol/L,respectively,all of which were significantly higher than those in the control group[(10.73±2.31)％,(37.86±3.56)μmol/L,(217.23±30.29)μmol/L,t=6.05,9.62,7.27,all P＜0.001].The level of malondialdehyde in the observation group was(4.32±0.87)mmol/L,which was significantly lower than that in the control group[(5.54±1.12)mmol/L,t=5.71,P＜0.001].The levels of superoxide dismutase[(94.53±6.73)kU/L]and glutathione peroxidase[(113.42±14.25)U/L]were significantly higher in the observation group compared with the control group[(80.41±7.78)kU/L,(94.53±12.47)U/L,t=9.10,6.62,both P＜0.001].Additionally,the levels of prealbumin[(308.94±27.43)mg/L],albumin[(39.74±1.98)g/L],and transferrin[(2.23±0.26)g/L]in the observation group were significantly higher than those in the control group[(267.85±31.24)mg/L,(36.43±2.47)g/L,(1.68±0.31)g/L,t=6.56,6.94,9.02,all P＜0.001].The C-reactive protein level in the observation group was(7.14±1.52)mg/L,which was significantly lower than that in the control group[(10.28±2.34)mg/L,t=7.46,P＜0.001].The hemoglobin level in the observation group was(112.52±6.67)g/L,which was significantly higher than that in the control group[(104.47±5.82)g/L,t=6.03,P＜0.001].Conclusion The combination of roxadustat and erythropoietin is significantly effective in treating hemodialysis and renal anemia.The combined therapy can reduce oxidative stress damage,improve nutritional status,and alleviate inflammatory response.
维普
万方数据
