Clinical efficacy of tacrolimus combined with Jisheng Shenqi pills and Sijunzi decoction in treating spleen-kidney deficiency type lupus nephritis in patients
Objective To investigate the clinical efficacy of tacrolimus combined with Jisheng Shenqi pills and Sijunzi decoction in treating spleen-kidney deficiency type lupus nephritis in patients.Methods A randomized controlled study was conducted on 82 patients with spleen-kidney deficiency type lupus nephritis admitted to Weinan Central Hospital from January 2019 to December 2023.The patients were divided into a control group(n=41)and an observation group(n=41)using the coin flip method.The control group was treated with tacrolimus,while the observation group received Jisheng Shenqi pills and Sijunzi decoction in addition to the control group's treatment.All patients were treated for 2 months.The clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,systemic lupus erythematosus disease activity index(SLE-DAI)scores,chronicity index(SLE-CI)scores,renal function(cystatin C,blood urea nitrogen,serum creatinine),high-sensitivity C-reactive protein,transforming growth factor β1,procalcitonin,silent information regulator 4(SIRT4)levels,and adverse reactions(gastrointestinal discomfort,dizziness,rash,liver function abnormalities)were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was significantly higher than that in the control group[95.12％(39/41)]vs.[80.49％(33/41),x2=4.10,P＜0.05).After treatment,the TCM syndrome scores,SLE-DAI scores,and SLE-CI scores in the observation group were(4.24±0.96)points,(9.04±1.40)points,(1.22±0.17)points,respectively,which were significantly lower than those in the control group[(8.13±1.06)points,(12.78±1.82)points,(1.37±0.19)points,t=17.41,10.42,3.76,all P＜0.05].The levels of cystatin C,blood urea nitrogen,and serum creatinine in the observation group were(1.49±0.42)mg/L,(5.20±1.30)mmol/L,(93.27±5.22)μmol/L,respectively,which were significantly lower than those in the control group[(2.16±0.46)mg/L,(6.26±1.27)mmol/L,(103.29±5.07)μmol/L,t=6.88,3.73,8.81,all P＜0.05].The levels of high-sensitivity C-reactive protein,transforming growth factor β1,and procalcitonin in the observation group were(3.24±0.87)mg/L,(32.27±6.57)μg/L,(14.11±2.34)μg/L,respectively,which were significantly lower than those in the control group[(4.48±0.81)mg/L,(40.34±7.52)μg/L,(18.26±2.79)μg/L,t=6.67,5.17,7.29,all P＜0.05],while the level of SIRT4 was significantly higher in the observation group[(0.47±0.06)mg/L]compared with the control group[(0.37±0.04)mg/L,t=8.87,P＜0.05].The incidence of adverse reactions in the observation group[4.87％(2/41)]was slightly,but not significantly,lower than that in the control group[14.63％(6/41),x2=2.21,P＞=0.05].Conclusion Tacrolimus combined with Jisheng Shenqi pills and Sijunzi decoction in treating spleen-kidney deficiency type lupus nephritis can significantly improve clinical efficacy,reduce TCM syndrome scores,SLE-DAI scores,and SLE-CI scores,improve renal function,alleviate inflammation,and has good safety.
Lupus nephritisKidney function testsC-reactive proteinBlood urea nitrogenTacrolimusJisheng Shenqi PillsSijunzi Decoction
维普
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