Application of multimodal imaging technology in the staging of cervical cancer and evaluation of pathological differentiation
Objective To analyze the application value of multimodal imaging technology in the staging of cervical cancer and evaluation of pathological differentiation.Methods A cross-sectional study was conducted to retrospectively analyze the clinical data of 83 patients with cervical cancer who received treatment at Xian Yang Central Hospital from February 2022 to September 2023.All patients underwent pelvic magnetic resonance imaging(MRI),including diffusion-weighted imaging(MRI-DWI)and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI).A double-blind method was used to compare the DWI parameters[apparent diffusion coefficient(ADC),slow diffusion coefficient(D),and fast diffusion coefficient(D*)]and DCE parameters[volume transfer constant(Ktrans),rate constant(Kep),and extracellular volume fraction(Ve)]among patients with different clinical stages and histological grades.The application value of multimodal MRI in the staging of cervical cancer and evaluation of pathological differentiation was analyzed.Results The ADC values in patients with cervical cancer at stage Ⅰ b and below were significantly higher than those in patients with cervical cancer at stages Ⅱa,Ⅱ b,and Ⅲ and above(F=7.90,P＜0.01).Conversely,the Ktrans,Kep,and Ve values were all lower in patients with cervical cancer at stage Ⅰ b and below than those in patients with cervical cancer at stages Ⅱa,Ⅱ b,and Ⅲ and above(F=8.12,7.64,3.13,all P＜0.01).For patients with cervical cancer at stage Ⅱ a,the ADC value was(0.84±0.15),which was higher than that of patients with cervical cancer at stage Ⅲ and above(0.76±0.07)(t=1.88,P=0.035).The Ktrans,Kep,and D*values were(0.29±0.09),(0.53±0.13),and(39.08±7.30),respectively,all of which were lower than those in patients with cervical cancer at stage Ⅲ and above[(0.39±0.12),(0.69±0.18),(49.04±6.72),t=-2.64,-2.85,-3.94,all P＜0.01].The ADC values in G1 grade patients were higher than those in G2 and G3 grade patients(F=4.26,P＜0.05),while the Ktrans,Kep,and D*values were all lower than those in G2 and G3 grade patients(F=8.14,6.83,6.81,all P＜0.05).Pearson correlation analysis showed that the histological grade of patients with cervical cancer was negatively correlated with the ADC value(r=-0.32,P=0.003)and positively correlated with the Ktrans,Kep,and D*values(r=0.43,0.35,0.28,all P＜0.05).Conclusion Multimodal imaging technology has good application value in evaluating the clinical staging and pathological differentiation of cervical cancer,making them worthy of clinical reference and application.
Uterine cervical neoplasmsMagnetic resonance imagingDiffusion magnetic resonance imagingNeoplasm stagingNeoplasm grading
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