Clinical study of restrictive versus liberal transfusion strategies for the treatment of anemia in preterm infants
Objective To analyze the effects of different transfusion thresholds(restrictive versus liberal transfusion)on the prognosis of anemia in preterm infants.Methods A retrospective study was conducted involving 80 preterm infants with anemia who received treatment at Jinhua People's Hospital from December 2019 to February 2022.The infants were divided into two groups based on different transfusion thresholds:the control group(restrictive transfusion)and the study group(liberal transfusion),with 40 patients in each group.Vital signs were recorded,and the transfusion and recovery outcomes were analyzed.Additionally,the occurrence of transfusion-related complications was calculated.Results In the study group,the heart rate[(142.41±8.39)beats/minute]and respiratory rate[(43.51±5.27)breaths/minute]24 hours after the last transfusion were significantly lower than those in the control group[(150.78±8.15)beats/minute,(48.76±5.49)breaths/minute],while the oxygen saturation[(96.21±1.47)％]was significantly higher than that in the control group[(94.59±1.82)％,t=-5.29,-5.77,6.38,all P＜0.05].There was no statistically significant difference in mean arterial pressure between the two groups(P＞0.05).The number of transfusions and total volume of blood transfused did not differ significantly between the two groups(both P＞0.05).The age at first transfusion,time to wean off ventilatory support,time to achieve full oral feeding,time to reach sufficient milk intake,and length of hospital stay in the study group were(12.46±2.91)days,(14.92±3.16)days,(16.34±3.36)days,(20.59±3.41)days,and(31.72±5.52)days,respectively.These values were significantly shorter than those in the control group[(18.85±3.27)days,(19.57±3.42)days,(21.86±3.58)days,(24.07±3.82)days,(36.49±5.76)days,t=-10.63,-7.35,-8.47,-5.63,-6.05,all P＜0.001].The incidence of bronchopulmonary dysplasia and brain injury in the study group was 12.5％(5/40)and 7.5％(3/40),respectively.These incidences were significantly lower than those in the control group[35.0％(14/40),25.0％(10/40),x2=5.59,4.50,both P＜0.05].Conclusion The use of restrictive transfusion strategies for treating anemia in premature infants does not increase the risk of transfusion exposure.Furthermore,it effectively improves the child's vital signs,promotes rapid recovery,and reduces the incidence of transfusion-related complications.
Infant,prematureAnemiaBlood transfusionVital signsPrognosisHeart rateArterial pressureLength of stay
NETL
NSTL
万方数据
