Clinical efficacy of different postoperative drug treatments for patients with stage Ⅳendometriosis
Objective To investigate the clinical efficacy of different postoperative drug treatments for patients with stage Ⅳ endometriosis.Methods A retrospective analysis was conducted on 100 patients with a recent need for fertility who underwent fertility-preserving surgery and were pathologically confirmed to have endometriosis after surgery at the Department of Gynecology of The First Affiliated Hospital of Bengbu Medical University between January 2020 and June 2023.Based on the different adjuvant drugs used for postoperative treatment,the patients were divided into two groups:the leuprolide group and the dienogest group,with 50 patients in each group.The therapeutic effects of the two groups were compared,including changes in sex hormone levels and severity of dysmenorrhea after treatment compared with before treatment.Additionally,pregnancy rate 1 year after surgery and the occurrence of adverse reactions were also monitored.Results After treatment,the serum levels of estradiol,luteinizing hormone,and follicle-stimulating hormone in the dienogest group were(35.77±6.28)ng/L,(0.50±0.03)IU/L,and(3.90±0.32)IU/L,respectively,and they were(23.36±6.09)ng/L,(0.30±0.02)IU/L,and(2.68±0.28)IU/L,respectively in the leuprolide group.All these measurements were significantly lower than those recorded before treatment in the corresponding group(t=40.15,112.95,36.25,27.87,124.87,75.86,all P＜0.05).After surgery,the Visual Analog Scale score in the dienogest group was significantly lower than that in the leuprolide group(t=-11.50,P＜0.05).Within 1 year after surgery,the pregnancy rate in the dienogest group was significantly higher than that in the leuprolide group(x2=3.90,P＜0.05).Conclusion Compared with postoperative intervention using leuprolide,dienogest as a postoperative drug therapy for patients with stage Ⅳ endometriosis demonstrated greater effectiveness in improving fertility and reducing the severity of dysmenorrhea.
EndometriosisEstradiolLuteinizing hormoneFollicle stimulating hormoneDysmenorrheaFertilityComparative effectiveness research
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