Objective To investigate the clinical application value of inflammatory factors in evaluating the condition and prognosis of elderly patients with severe pulmonary infection.Methods From May 2018 to April 2022,80 elderly patients with severe pulmonary infections in our hospital were selected as the observation group,while 80 elderly patients with mild pulmonary infections in the same period were selected as the control group.The levels of inflammatory factors in two groups were detected using ELISA method and The pulmonary infection score(CPIS)of both groups were evaluated;After 28 days of treatment in both groups,the relationship between inflammatory factor levels and patient condition,CPIS score,and prognosis were analyzed.Results IL-6(93.28±22.15)pg/mL,IL-8(552.14±184.32)pg/mL,PCT(6.32±2.28)mg/L and TNF-α(208.36±11.42)pg/mL in observation group were significantly higher than those in the control group[(21.36±7.36)pg/mL,(210.23±145.67)pg/mL,(0.93±0.17)mg/L,(103.28±16.62)pg/mL](P＜0.05).After 1 day of treatment in the observation group,IL-6(90.15±20.06)pg/mL,IL-8(549.36±180.21)pg/mL,PCT(6.32±2.28)mg/L,TNF-α(198.24±10.08)pg/mL were significantly higher than those 3 days after treatment[(79.26±18.42)pg/mL,(318.25±190.31)pg/mL,(5.42±1.86)mg/L,(178.14±16.05)pg/mL and 7 days after treatment[(63.12±10.28)pg/mL,(225.26±150.41)pg/mL,(3.23±0.32)mg/L,(135.27±20.06)pg/mL](P＜0.05).In the observation group,CPIS score was positively correlated with IL-6(r=0.704,P=0.002),IL-8(r=0.735,P=0.000),PCT(r=0.741,P=0.000),and TNF-α(r=0.693,P=0.003).IL-6(78.28±20.36)pg/mL,IL-8(472.42±121.36)pg/mL,PCT(4.42±1.86)mg/L and TNF-α(182.23±9.86)pg/mL in death group were significantly higher than those in the survival group[(24.52±8.24)pg/mL,(248.54±112.65)pg/mL,(1.23±0.122)mg/L,(115.14±12.01)pg/mL](P＜0.05).Conclusion Inflammatory factors are related to the severity and prognosis of elderly patients with severe pulmonary infection,which is one of the important causes of death.
维普
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