Objective The relationship between serum B7-H3 and haptoglobin(HPT)levels and the condition and prognosis of patients with sepsis was analyzed,and the influencing factors of poor prognosis were analyzed to construct a nomogram prediction model.Methods A total of 325 patients with sepsis admitted to Hanzhong 3201 Hospital from July 2018 to July 2021 were selected as the study group.According to whether there was shock,they were divided into septic shock group(105 cases)and septic non-shock group(220 cases).The 28-day survival of patients with sepsis was observed and divided into survival group(200 cases)and death group(125 cases).The general data of the patients were recorded.The serum indexes of the patients on the first day of admission were detected.The expression levels of serum B7-H3 and HPT were dynamically monitored by enzyme-linked immunosorbent assay.Logistic regression analysis model and R software were used to construct a nomogram to diagnose shock model and predict poor prognosis model in patients with sepsis.Hosmer-Lemeshow goodness of fit test,calibration curve and ROC curve were used to evaluate the diagnostic and predictive efficacy of the nomogram model constructed in this study.Results Serum B7-H3 was dynamically monitored at 1 day,2 days,7 days and 14 days after admission.HPT showed that the shock group was higher than the non-shock group,and the death group was always higher than the survival group.The difference was statistically significant(P＜0.05).Logistic regression analysis showed that neutrophil percentage(NEU),C-reactive protein(CRP),procalcitonin(PCT),serum creatinine(SCr),sequential organ failure score(SOFA),white blood cell count(WBC),platelet(PLT),B7-H3 and HPT were the influencing factors of poor prognosis in patients with sepsis(P＜0.05).On the first day of admission,the AUC of B7-H3 and HPT levels combined to predict the poor prognosis of sepsis patients was significantly better than that of each index alone(P＜0.05).The calibration curve and Hosmer-Lemeshow goodness of fit test the poor prognosis prediction model(M2)of sepsis patients,and the slope of the calibration curve was close to 1(P＞0.05).Conclusion The abnormal expression of B7-H3 and HPT in the serum of patients with sepsis is closely related to the patient's condition and prognosis,and the combination of the two improves the accuracy of predicting poor prognosis in patients with sepsis.
SepsisB7-H3HaptoglobinConditionPrognosisNomogram model
维普
万方数据
