Objective To investigate clinical effect of nitroglycerin combined with Shenfu injection in the treatment of acute ST segment elevation myocardial infarction(STEMI).Methods Sixty patients with acute STEMI admitted to People's Hospital of Luancheng District in Shijiazhuang City from January 2021 to June 2022 were selected as the study subjects.They were divided into control group(30 cases)and observation group(30 cases)by using random number table method.The control group received intravenous drip of nitroglycerin injection during pre-hospital emergency treatment,while observation group received intravenous drip of nitroglycerin combined with Shenfu injection during pre-hospital emergency treatment.Both groups received long-term treatment with conventional regimen after admission.Clinical treatment effect,vital sign indicators such as heart rate,oxygen saturation of blood,blood oxygen,and pain scores before and after treatment,cardiac troponin I(cTnI)levels at different times,cardiac function indicator after treatment of two groups were compared.Results Clinical treatment effect of observation group was better than that of control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in heart rate,systolic oxygen saturation of blood,diastolic oxygen saturation of blood,blood oxygen and pain scores between two groups(P>0.05).After treatment,heart rates of two groups were slower than those before treatment,systolic oxygen saturation of blood,diastolic oxygen saturation of blood and blood oxygen of two groups were higher than those before treatment,pain scores of two groups were lower than those before treatment,and heart rate of observation group was slower than that of control group,systolic oxygen saturation of blood,diastolic oxygen saturation of blood and blood oxygen of observation group were higher than those of control group,and pain score of observation group was lower than that of control group,and the differences were statistically significant(P<0.05).Overall analysis found that there were statistically significant differences in cTnI levels between groups,time points,and interactions(P<0.05).Further pairwise comparison,intra group comparison:cTnI levels at six,12,and 24 hours after medication in both groups were lower than those at the time of admission,cTnI levels at 12 and 24 hours after medication in both groups were lower than those at six hours after medication,cTnI levels at 24 hours after medication in both groups were lower than those at 12 hours after medication,and the differences were statistically significant(P<0.05).group comparison:cTnI levels in observation group were lower than those in control group at the time of admission,six hours after medication,12 hours after medication,and 24 hours after medication,and the differences were statistically significant(P<0.05).Three months after treatment,left ventricular ejection fraction,E-peak and E/A in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference between two groups of A-peak(P>0.05).Conclusion Both nitroglycerin and nitroglycerin combined with Shenfu injection can achieve a certain therapeutic effect in the treatment of acute STEMI,but nitroglycerin combined with Shenfu injection has a better effect.
Acute ST-segment elevation myocardial infarctionCoronary heart diseaseNitroglycerin injectionShenfu injectionPre-hospital first aidCardiovascular system diseases
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