Objective To compare the effect of conversion to sinus rhythm in patients with paroxysmal atrial fibrillation in emergency department.Methods A total of 76 patients with PAF admitted from June 2019 to January 2021 were randomly divided into the pharmacological cardioversion group and the electrical cardioversion group.Chi-square test and t-test were used to compare the efficacy differences between electrical cardioversion and pharmacological cardioversion.Results Compared with the shock group,33 cases(100.00%)and 40 cases(93.00%)in the drug shock group were converted to sinus rhythm(absolute difference 6.98%;95%CI:from-0.82 to 0.98;P=0.25).The median time from infusion to conversion in the drug shock group was 24 min(IQR 21.00-82.00),but only 9 cases(27.00%)were converted by procainamide.The results at 14 days were similar between the two groups,with no strokes or deaths reported.Conclusion This study found that compared to electrical cardioversion,pharmacological cardioversion had a more significant effect in converting emergency patients with PAF to sinus rhythm.It is worth promoting the clinical use of pharmacological cardioversion.