Objective Traumatic brain injury(TBI)is a leading cause of death and disability in children,resulting in significant hospital costs.This study aims to describe the clinical characteristics and acute treatment cost characteristics of hospital-based pediatric TBI.Methods This study conducted a retrospective observational study on all pediatric TBI patients in a tertiary hospital in China from 2015 to 2020.Taking the total acute hospitalization cost as the primary endpoint,linear regression was performed to analyze the predictive factors of pediatric TBI hospitalization costs.Results A total of 208 children patients were included in this study.The median cost of acute treatment was US$2 036(IQR,529-4 212),and the median length of stay was 6 days(IQR,4-8).Children in every age group have more falls than traffic accidents.In multiple linear regression analysis,prolonged hospitalization,age 12-18 years,surgery and ICU admission were predictors of hospitalization costs(P<0.05).Conclusion This study has potential significance for health care resource planning during the treatment of children's TBI.Strengthening family safety education,preventing the danger of young children falling from the bed,and strengthening the control of mopeds will help reduce the acute hospitalization costs of PTBI.