首页|20%脂肪乳静脉滴注联合血液净化救治有机磷农药中毒的临床效果

20%脂肪乳静脉滴注联合血液净化救治有机磷农药中毒的临床效果

The efficacy of 20.0%fat emulsion combined with blood purification in the treatment of organophosphorus pesticide poisoning and its impact on liver and kidney function and inflammatory response

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目的 探究 20%脂肪乳静脉滴注联合血液净化对有机磷农药中毒患者救治的疗效.方法 2020 年 1 月—2023 年 6 月成都市龙泉驿区第一人民医院有机磷农药中毒患者 102 例,随机分为对照组 51 例及观察组 51 例.对照组接受血液净化救治,观察组在对照组的基础上联合 20%脂肪乳静脉滴注治疗.比较两组疗效.结果 102 例患者中,治疗总有效共 92 例,总有效率为 90.20%.与对照组相比,观察组总有效率更高(96.08%vs.84.31%),差异有统计学意义(P<0.05);与对照组相比,观察组患者苏醒时间更短,住院时间更短,差异有统计学意义(P<0.05).治疗前,两组胆碱酯酶水平比较差异无统计学意义(P>0.05);治疗 6h至治疗 36 h,观察组胆碱酯酶水平高于对照组,差异有统计学意义(P<0.05).治疗后,两组患者TBIL、AST、ALT、TNF-α、CRP、IL-6均出现下降,且观察组低于对照组(P<0.05).结论 20%脂肪乳静脉滴注联合血液净化可提升有机磷农药中毒患者救治疗效,能改善肝肾功能,降低炎性反应.
Objective Exploring the efficacy of intravenous infusion of fat emulsion combined with blood purification in the treatment of patients with organophosphorus pesticide poisoning.Methods From January 2020 to June 2023,102 patients with organophosphorus pesticide poisoning at the First People's Hospital of Longquanyi District,Chengdu were randomly divided into a control group of 51 cases and an observation group of 51 cases.The control group received blood purification treatment,while the observation group received intravenous infusion of fat emulsion in addition to the control group.Compare the therapeutic effects of two groups.Results Among the 102 patients,the total effective rate was 90.20%in 92 cases.Compared with the control group,the total response rate was higher in the observation group(96.08%vs.84.31%),and the difference was significant(P<0.05).Compared with the control group,the patients in the observation group had a shorter awakening time and a shorter hospitalization time,indicating statistical significance(P<0.05).Before treatment,there was no significant difference between the two groups(P>0.05).After treatment from 6 hours to 36 hours,the observation group was significantly higher than that of the control group,with a statistically significant difference(P<0.05).After treatment,TBIL,AST and ALT decreased in both groups,and the observation group was lower than the control group(P>0.05).After treatment,TNF-α,CRP,and IL-6 decreased in both groups,and the observation group was lower than the control group(P>0.05).Conclusion 20.0%fat emulsion combined with blood purification can improve the treatment effect of patients with organophosphorus pesticide poisoning,improve liver and kidney function and inflammatory reactions,and enhance rehabilitation efficiency.

Fat emulsionBlood purificationOrganic phosphorus pesticide poisoningLiver and kidney functionInflammatory reactions

蒋雄、彭俊、黄益

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成都市龙泉驿区第一人民医院,四川成都 610100

四川护理职业学院附属医院(四川省第三人民医院),四川成都 610100

脂肪乳 血液净化 有机磷农药中毒 肝肾功能 炎性反应

四川省医学科开课题(2022)

S22027

2024

中国急救复苏与灾害医学杂志
中国医学救援学会

中国急救复苏与灾害医学杂志

CSTPCD
影响因子：0.568
ISSN：1673-6966
年,卷(期)：2024.19(6)