Objective To investigate the difference between oXiris filter and ordinary filter in the treatment of ICU patients with septic shock and acute kidney injury.Methods Seventy-eight patients admitted to Hechi City People's Hospital with septic shock with acute kidney injury in ICU from April 2018 to December 2021 were selected and divided into oXiris group and conventional group according to the different filters used,39 cases each.oXiris filters were used in the oXiris group and conventional filters were used in the conventional group.The inflammatory mediators[calcitoninogen(PCT),endotoxin,interleukin-6(IL-6),interferon-gamma(IFN-γ),C-reactive protein(CRP)],hemodynamic and respiratory conditions[heart rate(HR),blood lactate(Lac),mean arterial pressure(MAP)],renal function[blood creatinine(Cr),blood urea nitrogen(BUN)],acute physiological and Acute Physiology And Chronic Health Evaluation(APACHE)Ⅱ score,Sequential Organ Failure Assessment(SOFA)score,recovery process Icu hospitalization time(duration of continuous renal replacement therapy(CRRT)],norepinephrine use,and 28-day survival prognosis.Results(1)PCT,endotoxin,IL-6,IFN-γ,CRP,HR,Lac were lower in the oXiris group and MAP was higher in the conventional group after 24 hours and 48 hours of treatment(P<0.05);(2)Cr,BUN,APACHE Ⅱ score,SOFA score were lower in the oXiris group than in the conventional group after 24 hours and 48 hours oXiris treatment(P<0.05);(3)The ICU stay and CRRT duration were shorter in the oXiris group than in the conventional group,and the use of norepinephrine after 24 hours and 48 hours of treatment was lower than in the conventional group(P<0.05);(4)The survival rate of oxiris group was 89.74%(35/39),which was higher than that of conventional group 74.36%(29/39)(P>0.05).Conclusion Compared with the ordinary filter,oxiris filter can better improve the respiratory function and renal function of patients with septic shock and acute kidney injury in ICU,stabilize the hemodynamics of patients,reduce inflammatory injury,reduce the use of norepinephrine,promote the recovery of patients'condition,and further improve the survival rate.
维普
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