Objective To analyze the expression and significance of neuron specific enolase(NSE)in patients with acute lymphoblastic leukemia(ALL).Methods Eighty-six cases of ALL received in our hospital from March 2021 to March 2023 were selected as the observation group,and 65 healthy patients who came to our hospital for physical examination at the same time were selected as the control group.All subjects were measured for their serum NSE levels,and the differences in NSE levels between the two groups of subjects were compared.According to the condition of the observation group,they were divided into central nervous system leukemia(CNSL group,31 cases)and non CNSL group(55 cases).Compare the relevant laboratory indicators(WBC,Hb,IL-10,PLT,RBC)and NSE levels between two groups of patients.Establish a subject work curve to evaluate the diagnostic and differential value of NSE between ALL and CNSL.Results The NSE level in the CNSL group was higher than that in the non-CNSL group and the control group,and the difference between the three groups was statistically significant(P<0.05).Compared with the non-CNSL group,patients in the CNSL group had significantly higher levels of WBC and IL-10,and the difference was statistically significant(P<0.05).The level of NSE in patients with ALL was positively correlated with the levels of WBC and IL-10(P<0.05),and there was no significant correlation with Hb,RBC,and PLT(P>0.05).The area under the ALL curve of NSE level diagnosis was 0.799,the sensitivity and specificity were 0.663 and 0.938,respectively,the cut-off value was 11.360 μg/L,and the Youden's J statistic was 0.601;The area under the curve for the identification of ALL type by NSE level was 0.961,the sensitivity and specificity were 0.903 and 0.964,respectively,the cut-off value was 13.320,and the Youden's J statistic was 0.867.Conclusion NSE has abnormal expression in ALL patients,and the degree of abnormality is more pronounced in CNSL type patients.NSE can provide a certain reference for clinical diagnosis and differentiation of ALL types.
Neuron specific enolaseAcute lymphoblastic leukemiaCentral nervous system leukemiaDiagnosisdistinguish
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