Objectives To evaluate the effectiveness and safety of oxycodone preemptive analgesia regimen in surgical patients by systematic review and Meta-analysis method.Methods Computerized searches were performed on PubMed,Medline,Web of Science,Embase,Cochrane Library,China Academic Journal Full Text Database(CNKI),China Biomedical Literature Data on CD-ROM(CBM disc),and Vip database(VIP).Various types of studies related to oxycodone hyperalgesia were included,and the search period was from the establishment of the database to June 30th 2023.Evaluation metrics included:postoperative visual scores of patient pain,and rates of related postoperative complications.Statistical analysis was performed using RevMan 5.4 and SPSS 23.0 software.Results A total of 13,810 articles were retrieved,and 15 articles met the inclusion criteria for the systematic review.Among them,10 randomized controlled trials(RCTs)were included in the meta-analysis,involving 890 cases.Compared with patients in the control group(saline or placebo),patients in the oxycodone preemptive analgesia group had postoperative 8h/12h pain VIS scores(IV=-1.00,95%CI:from-1.21 to-0.78,P<0.001),postoperative 4 h/6 h pain VIS scores(IV=-1.06,95%CI:from-1.50 to-0.62,P<0.001),24 h postoperative pain VIS score(IV=-0.53,95%CI:from-0.86 to-0.20,P=0.002)were significantly different,and the pain scores of patients in the oxycodone preemptive analgesia group were lower;there was a significant difference in the incidence of postoperative adverse reactions between the two groups of patients(OR=0.34,95%CI:0.17-0.7,P=0.003),and the incidence of adverse reactions of patients in the oxycodone preemptive analgesia group was lower,and the differences were all statistically Significance.Conclusion The preemptive analgesia protocol with hydrocodone can be widely applied in the anesthetic practice of surgical procedures,and its effectiveness and safety have been validated.It offers advantages such as lighter postoperative pain in patients and a lower incidence of adverse reactions.
维普
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