Objective To investigate the correlation between Polymyxin B(PMB)concentration and PMB related acute kidney injury in critically ill patients.Methods The clinical data of 120 severe patients treated with intravenous PMB from August 2021 to July 2023 in our hospital were retrospectively analyzed,and they were divided into acute renal injury group and non-acute renal injury group according to whether PMB related acute renal injury occurred.The clinical data of the two groups were compared,and the risk factors of PMB-related acute kidney injury in severe patients were analyzed by univariate and multivariate Logistic regression.Receiver Operating Characteristic(ROC)curves were drawn to analyze the efficacy of PMB drug concentration parameters in predicting the occurrence of PMB-associated acute kidney injury in critically ill patients.Results Among 120 critically ill patients,33(27.50%)were diagnosed with PMB-associated acute kidney injury.Vancomycin application ratio,C1/2 and Cmin in acute renal injury group were significantly higher than those in non-acute renal injury group(P<0.05).Logistic regression analysis showed that C1/2 and Cmin were independent risk factors for PMB-related kidney injury in severe patients(P<0.05).ROC curve results showed that the AUC of C1/2 was 0.798(95%CI:0.695-0.901),the best diagnostic value was 3.421 mg/L,and the corresponding sensitivity,specificity and Jorden index were 60.61%,89.65%and 0.5026,respectively.The AUC of Cmin was 0.676(95%CI:0.558-0.795),the best diagnostic value was 2.284 mg/L,and the corresponding sensitivity,specificity and Jorden index were 66.67%,73.56%and 0.4023,respectively.Conclusion The occurrence of PMB-associated acute kidney injury in critically ill patients is related to the concentration of PMB,and C1/2 and Cmin can be used as predictors of the occurrence of PMB-associated acute kidney injury during PMB treatment.
维普
万方数据
