Objective Exploring the predictive value of peripheral blood thioredoxin-1(TRX-1),vascular endothelial growth factor(VEGF)combined with nitric oxide(NO)/endothelin-1(ET-1)ratio(NO/ET-1)in predicting vascular dementia(VaD)in elderly patients with acute cerebral infarction(ACI).Methods Retrospective collection of clinical data from 104 elderly ACI patients at Changsha Eighth Hospital from May 2021 to May 2023.Patients were divided into VaD group(n=38)and Non-VaD group(n=66)based on whether they were complicated with VaD.The clinical data of the two groups were compared,and a multivariate Logistic regression model was used to analyze the risk factors for ACI complicated with VaD.Receiver Operating Characteristic(ROC)curves were used to analyze the predictive value of serum TRX-1,VEGF levels,and NO/ET-1 for VaD in elderly ACI patients.Results The age,hs CRP,diabetes,hypertension and hyperlipidemia in VaD group were higher than those in Non-VaD group,while TRX-1,VEGF,NO/ET-1 were lower than those in Non-VaD group(P<0.05);Age,diabetes,hypertension,hyperlipidemia and serum TRX-1,VEGF,NO/ET-1 were all independent risk factors for VAD in ACI patients(P<0.05).The expression levels of serum TRX-1,VEGF,and NO/ET-1 were positively correlated in both VaD and Non-VaD groups;The combined prediction of TRX-1,VEGF,and NO/ET-1 for VaD in ACI patients has an AUC of 0.713.Conclusion Serum TRX-1,VEGF,and NO/ET-1 are independent risk factors for VaD in elderly ACI patients and can serve as biomarkers for predicting VaD.
维普
万方数据
