Relationship between elevated plasma pentraxin 3 level and quantitative CT,pulmonary function and clinical events in patients with combined pulmonary fibrosis with emphysema
Objective To analyze the relationship between the elevated level of plasma pentamer protease 3(PTX3)and objective quantified computed tomography(CT)measurements,pulmonary function examination(PFT)results and clinical events in patients with pulmonary fibrosis and emphysema(CPFE).Methods A total of 46 CPFE patients who came to our hospital from January 2018 to January 2023 were recruited.The plasma PTX3 level was detected by ELISA,and the range of emphysema lesions was obtained by calculating the percentage of low attenuation area(%LAA).The range of fibrotic lesions was calculated as a percentage of high attenuation area(%HAA).The%LAA and%HAA values were combined to produce the percentage of abnormal areas(%AA),and clinical events such as readmissions,acute episodes,and death were followed.Results By Spearman rank correlation analysis,plasma PTX3 level in CPFE patients was correlated with FEV1%pred(rs=-0.320,P=0.030),FEV1/FVC(rs=-0.540,P<0.001),TLC%pred(rs=-0.420,P=0.030),FEV1/FVC(rs=-0.540,P<0.001).P=0.004),DLCO%pred(rs=-0.341,P=0.020)were negatively correlated;It was positively correlated with%LAA(rs=0.551,P<0.001),%HAA(rs=0.338,P=0.022)and%AA(rs=0.548,P<0.001).Compared with patients without clinical events,plasma PTX3 levels were higher in readmitted patients(n=8)[875.60(676.0,1154.40)pg/mL vs.243.40(185.20,321.20)pg/mL,P<0.05].Plasma PTX3 was an excellent predictor of readmission risk in CPFE patients,with an area under the subject operating characteristic curve of 0.990 and sensitivity and specificity of 100.0%and 94.7%,respectively.However,in the multivariate analysis,only%AA was found to have the strongest association with hospitalization events(P=0.029).Conclusion The increase of plasma PTX3 level in CPFE patients is related to objective quantitative CT parameters,PFT results and patient readmission.
维普
万方数据
