射波刀治疗肝癌对外周血淋巴细胞的影响
Effect of CyberKnife radiotherapy on peripheral blood lymphocytes of liver cancer
傅华 1魏莹 2李莎 2占海莉 2牛冰冰 2张超2
作者信息
- 1. 中国人民解放军联勤保障部队第九四〇医院肿瘤科,甘肃 兰州 730050
- 2. 中国人民解放军联勤保障部队第九四〇医院放疗科,甘肃 兰州 730050
- 折叠
摘要
目的 探讨射波刀治疗的不同分割剂量、分割方式等相关参数对肝癌患者外周血淋巴细胞计数的影响.方法 回顾性分析在我院使用射波刀治疗的90例肝癌患者的临床资料.检测患者射波刀治疗前1周及治疗后1周、1个月、3个月的外周血淋巴细胞计数;分析射波刀不同处方剂量、分割剂量、分割次数对外周血淋巴细胞计数的影响.结果 与治疗前1周比较,不同处方剂量、分割剂量及分割方式的患者在射波刀治疗后外周血淋巴细胞计数出现不同程度下降(P<0.05).治疗后1周、1个月,分割次数≤5次组和分割剂量>7 Gy组患者的外周血淋巴细胞计数分别显著高于分割次数>5次组和分割剂量≤7 Gy组(P<0.05).不同处方剂量的患者在射波刀治疗前后淋巴细胞计数差异无统计学意义(P>0.05).结论 射波刀治疗肝癌时给予分割次数≤5次、分割剂量>7 Gy的治疗方案,更有利于减轻射波刀治疗所导致的淋巴细胞数量下降.
Abstract
Objective To explore the effects of different fractionation doses,fractionation methods,and other related parameters on the peripheral blood lymphocyte count of patients with liver cancer receiving CyberKnife radiotherapy.Methods The clinical data of 90 patients with liver cancer receiving CyberKnife radiotherapy in our hospital were retrospectively analyzed.The peripheral blood lymphocyte counts of patients 1 week before CyberKnife radiotherapy and 1 week,1 month and 3 months after treatment were determined.The effects of different prescribed doses,fractionation doses and numbers of fractionations on the peripheral blood lymphocyte count were analyzed.Results The peripheral blood lymphocyte counts of patients with different prescribed doses,fractionation doses and fractionation methods after CyberKnife treatment decreased to varying degrees compared with those 1 week before treatment(P<0.05).The peripheral blood lymphocyte counts of patients in the groups with≤5 fractionations and fractionation dose>7 Gy were significantly higher than those of patients in the groups with>5 fractionations and the fractionation dose≤7 Gy,respectively(P<0.05).There was no significant difference in peripheral blood lymphocyte counts between patients with different prescribed doses before and after CyberKnife treatment(P>0.05).Conclusion CyberKnife in the treatment of liver cancer with≤5 ractionations and a fractionation dose of>7 Gy is more beneficial to alleviate the decrease of lymphocyte count caused by Cyberknife treatment.
关键词
肝癌/射波刀/淋巴细胞计数/免疫治疗Key words
liver cancer/Cyberknife/lymphocyte count/immunotherapy引用本文复制引用
基金项目
甘肃省自然科学基金(22JR5RA003)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据