马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤的临床研究
Clinical study of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma
张均秀 1齐帅 2高磊3
作者信息
- 1. 保定市儿童医院皮肤科,河北 保定 071000
- 2. 石家庄市栾城人民医院普外科,河北 石家庄 051430
- 3. 保定市第一医院皮肤科,河北 保定 071066
- 折叠
摘要
目的 探究马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤的临床效果.方法 将240例皮肤血管瘤患儿随机分为对照组(120例)和联合组(120例),其中对照组患儿给予马来酸噻吗洛尔治疗,联合组患儿给予马来酸噻吗洛尔联合冷冻治疗.比较2组患儿临床疗效、瘤体直径、血清基质金属蛋白酶-9(MMP-9)水平、血管内皮生长因子(VEGF)水平及不良反应发生情况.结果 联合组患儿治疗总有效率明显高于对照组(P<0.05).与治疗前比较,治疗后3个月、治疗后6个月2组患儿瘤体直径均逐渐减小(P<0.05),且联合组患儿治疗后3个月、治疗后6个月瘤体直径减小更明显(P<0.05).与治疗前比较,治疗后3个月、治疗后6个月2组患儿血清MMP-9及VEGF水平均逐渐降低(P<0.05),且联合组患儿治疗后3个月、6个月MMP-9及VEGF水平均明显低于对照组(P<0.05).2组患儿湿疹、溃疡、糜烂及红肿等不良反应总发生率比较,差异无统计学意义(P>0.05).结论 马来酸噻吗洛尔联合冷冻治疗婴幼儿皮肤血管瘤疗效显著,可有效降低血清MMP-9、VEGF水平,缩小瘤体,安全有效.
Abstract
Objective To explore the clinical effect of timolol maleate combined with cryotherapy for infantile cutaneous hemangioma.Methods A total of 240 infants with cutaneous hemangioma were randomly divided into the control group(120 cases)and the combined group(120 cases).The control group was treated with timolol maleate,and the combined group was treated with timolol maleate combined with cryotherapy.The clinical efficacy,tumor diameter,levels of serum matrix metalloproteinase-9(MMP-9)and vascular endothelial growth factor(VEGF)and the occurrence of adverse reactions of the two groups were compared.Results The total effective rate of the combined group was significantly higher than that of the control group(P<0.05).Compared with before treatment,the tumor diameter 3 months and 6 months after treatment in the two groups gradually decreased(P<0.05),and the tumor diameter 3 months and 6 months after treatment in the combined group decreased more obviously(P<0.05).Compared with before treatment,the levels of serum MMP-9 and VEGF 3 months and 6 months after treatment in the two groups gradually decreased(P<0.05),and the levels of serum MMP-9 and VEGF 3 months and 6 months after treatment in the combined group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions such as eczema,ulcer,erosion or redness between the two groups(P>0.05).Conclusion Timolol maleate combined with cryotherapy for infantile cutaneous hemangioma has significant curative effect,which can effectively reduce the levels of serum MMP-9 and VEGF,and shrink the tumor body,with safety and effectiveness.
关键词
婴幼儿皮肤血管瘤/冷冻疗法/马来酸噻吗洛尔/血管内皮生长因子/基质金属蛋白酶-9Key words
infantile cutaneous hemangioma/cryotherapy/timolol maleate/vascular endothelial growth factor/matrix metalloproteinase-9引用本文复制引用
基金项目
河北省卫生计生委科研项目(20190186)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据