Correlation between serum hypersensitive C-reactive protein/albumin and contrast-induced nephropathy after PCI for acute coronary syndromes
Objective To analyze the correlation between serum hypersensitive C-reactive protein(hs-CRP)/albumin(Alb)and contrast-induced nephropathy after percutaneous coronary intervention(PCI)in patients with acute coronary syndromes.Methods A total of 496 patients with acute coronary syndromes who underwent PCI in our hospital were selected as the research subjects,and divided into the contrast-induced nephropathy group(n=56)and the non-contrast-induced nephropathy group(n=440)according to whether the contrast-induced nephropathy occurred after PCI.The preoperative serum level of hs-CRP was determined by ELISA,the preoperative serum Alb level was determined by hematology analyzer,and the hs-CRP/Alb was calculated.Logistic regression was used to analyze the factors influencing the occurrence of contrast-induced nephropathy after PCI in patients with acute coronary syndromes.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum hs-CRP/Alb in contrast-induced nephropathy after PCI for acute coronary syndromes.Results Compared with the non-contrast-induced nephropathy group,the preoperative serum hs-CRP level and hs-CRP/Alb of patients in the contrast-induced nephropathy group both significantly increased(P<0.001),and the Alb level significantly decreased(P<0.001).Compared with the non-contrast-induced nephropathy group,the preoperative creatinine level and contrast dose of patients in the contrast-induced nephropathy group both increased(P<0.05);the postoperative creatinine level of patients in the contrast-induced nephropathy group was higher than that before operation(P<0.05),and the postoperative serum uric acid of patients was lower than that before operation(P<0.05).Logistic regression analysis showed that the hs-CRP,hs-CRP/Alb,creatinine level,and contrast dose were the risk factors for the occurrence of contrast-induced nephropathy after PCI in patients with acute coronary syndromes(P<0.05),and the Alb was a protective factor(P<0.05).ROC curve showed that the area under the curve of serum hs-CRP/Alb was 0.965 in predicting contrast-induced nephropathy after PCI in patients with acute coronary syndromes,with a cut-off value of 0.19.Conclusion Higher preoperative serum hs-CRP/Alb of patients with acute coronary syndromes was associated with the development of contrast-induced nephropa-thy after PCI,which has certain predictive value for the development of contrast nephropathy after PCI in acute coronary syndromes.
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维普
