Clinical significance of FEN1 regulating the occurrence and prognosis of hepatocellular carcinoma
Objective To analyze the relationship between flap endonuclease 1(FEN1)and the occurrence and prognosis of hepatocellular carcinoma(HCC).Methods HCC tissues from 91 HCC patients(the HCC group)and LC tissues from 90 liver cirrhosis patients(the LC group)who admitted to department of hepatobiliary surgery in our hospital from May 2017 to October 2022 were selected,and the preopera-tive serum samples of all patients were collected.Additionally,serum samples from 90 healthy volunteers were included as controls.The expression of FEN1 in tissues was analyzed by immunohistochemistry,and the serum FEN1 level was detected by enzyme-linked immunosor-bent assay.The 5-year disease free survival(DFS)and overall survival(OS)of HCC patients were recorded.Results The serum FEN1 levels in the LC group and the HCC group were higher than those in the control group,and the differences were statistically significant(P<0.05).The H score of FEN1 protein expression in HCC tissues was positively correlated with the serum FEN1 level(rs=0.726,P<0.001).The area under the curve(AUC)of serum FEN1 in diagnosing HCC or differentiating HCC from LC were 0.943 and 0.897,respectively.Serum FEN1 level>244.74 pg/mL was an independent risk factor for 5-year DFS rate and OS rate in HCC patients(P<0.05).Conclusion FEN1 is overexpressed in HCC tissues and serum samples,and is positively correlated with poor prognosis of HCC patients,which can be used as a biomarker for early diagnosis and prognosis evaluation in HCC patients.
万方数据
维普
